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Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity — Ceccy  

Breast Cancer Clinical Trial

Official title:
Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity. A Randomized Double Blind Study.

Clinical Trial Summary

The purpose of this study is to evaluate if carvedilol can prevent the cardiotoxicity after chemotherapy in breast cancer.

Clinical Trial Description

Dilated cardiomyopathy secondary to chemotherapy accounts for approximately 1% of all dilated cardiomyopathies.

Initial studies showed beneficial effect of the use of carvedilol for the prevention of chemotherapy-induced cardiomyopathy. This study has the objective to evaluate the effectiveness of carvedilol for the prevention of chemotherapy-induced cardiomyopathy. Will be selected 200 patients referred for chemotherapy that includes anthracyclines for breast cancer.These patients will be randomized to carvedilol or placebo and will have periodic assessment of cardiac function with echocardiography and biomarkers until complete chemotherapy and 24 months later. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01724450
Study type Interventional
Source University of Sao Paulo
Contact
Status Completed
Phase Phase 3
Start date April 2013
Completion date June 2017
View Details
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