Breast Cancer Recurrent Clinical Trial
Official title:
Breast Cancer Recurrence - the Accuracy of Dual-time PET/CT
The purpose of this study is to elucidate the value of dual-time-point PET/CT in the
recurrence of breast cancer and to determine whether the method is better than the
modalities used in the standard work up.
150 patients with suspected breast cancer recurrence will be included. All patients will
undergo dual-time-point PET/CT, CT of thorax and upper abdomen and bone scintigraphy. After
completion of the examinations the early and the late PET/CT scan will be compared with each
other, the diagnostic CT-scan and the bone scintigraphy. A verification of suspicious
findings will be done by biopsy, if the area is accessible. If a biopsy cannot be obtained,
the presence of recurrence will be verified with additional imaging follow-up to ensure the
highest possible confidence. Sensitivity, specificity, accuracy, negative and positive
predictive value (NPV/PPV) will be calculated for each modality (incl. early and late
PET/CT).
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
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