Breast Cancer Clinical Trial
Official title:
Triple Negative Breast Cancer: Study of Molecular and Genetic Factors
Breast cancer triples negatives (TN; 15 % of the cases) are characterized by a high
histoprognostic grade, a strong proliferation, a strong metastatic power, and a worse
prognosis than the other forms of breast cancer. It is however a heterogenous group for
histological and molecular level, but also for evolution. Most of the TN is part of the
basal breast cancer subcategory. Until now, the medical treatment is based on chemotherapy.
Breast cancers by constitutional mutation of BRCA1 / BRCA2 (5 % of breast cancers) are
mostly of basal type and their prognostic seems better that what could be expected from high
grade tumours and without hormonal receptors. They would be much more frequent in the TN
group. However, at this day, no prospective study was led to estimate this incidence, or to
study the intervention of other genes of predisposition, as well to analyse the links
between this phenotype and their consequences at the germinal or somatic level, in terms of
associated molecular changes and prognosis.
The purpose of this study is, on a prospective study, to lead a joined analysis at the
germinal level, in search of mutations of the main genes of breast cancer predisposition
(BRCA1/2, PALB2, PTEN, PALB2), and at the tumour level (tissue micro-array and
transcriptome), by correlating these results to the main clinical parameters.
The 5 years relapse-free survival will also be estimated.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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