Breast Cancer Clinical Trial
Official title:
A Genome-Wide Association Study in Patients Experiencing Musculoskeletal Adverse Events on NCIC CTG Trial MA.27 Evaluating Aromatase Inhibitors as Adjuvant Therapy in Early Breast Cancer. A Collaboration Between the NIH Pharmacogenetics Research Network and the RIKEN Yokohama Institute Center for Genomic Medicine.
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.
PURPOSE: This research study is looking at tumor and blood samples from postmenopausal women
with primary breast cancer enrolled on clinical trial CAN-NCIC-MA27.
OBJECTIVES:
Primary
- To identify genetic variation, as measured by single nucleotide polymorphisms, that is
associated with musculoskeletal adverse events in specimens from postmenopausal women
with hormone receptor-positive primary breast cancer receiving adjuvant aromatase
inhibitors and enrolled on clinical trial CAN-NCIC-MA27.
OUTLINE: This is a multicenter study.
DNA from tumor tissue and blood specimens that have been previously collected from patients
are analyzed for single nucleotide polymorphisms.
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