Automating Breast Radiation Therapy (RT)

Breast Cancer Clinical Trial

Official title:

Automating the Breast Radiation Therapy Process to Improve Efficiency

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00923871
• Other study ID #: UHN REB 09-0197-CE
• Status: Completed
• Phase: N/A
• Start date: June 2009
• Est. completion date: April 29, 2016

Study information

• Verified date: October 2022
• Source: University Health Network, Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Breast radiation treatment is planned from a Computed Tomography (CT) scan. This study is designed to investigate a method to reduce the time between the planning of radiation treatment and its actual start by automating the intensity-modulated radiation therapy (IMRT) planning process. The investigators plan to examine data from another scan called Cone Beam Computed Tomography (CBCT). A CBCT scan provides similar information to a conventional CT scan, however the images for CBCT are acquired at the treatment unit (linear accelerator used for treatment). Using these x-ray pictures of patients, the study team consisting of a radiation oncologist, a medical physicist and a radiation therapist will create a custom treatment plan unique to each patient. By doing this, the investigators hope to reduce the amount of time spent waiting for treatment and the number of hospital visits for patients in the future.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 160
• Est. completion date: April 29, 2016
• Est. primary completion date: January 5, 2015
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with breast cancer who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.

• Patients with any stage of breast cancer.

• Patients with prior treatment such as surgery or chemotherapy for any type of cancer.

• Able to provide a written informed consent.

• 18 years of age or older.

Exclusion Criteria:

• < 18 years of age.

• Unable to provide informed consent.

• Males.

• Patients who received partial breast radiation and not the standard dose.

• Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions.

Related Conditions & MeSH terms

• Breast Cancer
• Breast Neoplasms

Intervention

Procedure:
• Cone Beam CT
Patients will also have a CBCT scan when they are having their first IMRT treatment.

Locations

Country	Name	City	State
Canada	University Health Network, Princess Margaret Hospital	Toronto	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
University Health Network, Toronto	Princess Margaret Hospital, Canada

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To generate on-line IMRT treatment plans using automated tools based on CBCT images acquired at the treatment unit.		3 years