Breast Cancer Clinical Trial
Official title:
Molecular Markers in Native American Women With Breast Cancer
RATIONALE: Studying samples of tumor tissue in the laboratory from Native American women
with breast cancer may help doctors identify and learn more about biomarkers related to
breast cancer in these patients. It may also help doctors learn more about the prognosis of
these patients.
PURPOSE: This laboratory study is looking at biomarkers in Native American women with breast
cancer.
OBJECTIVES:
- Evaluate a selected panel of molecular markers in tissue specimens from Native American
women with breast cancer.
- Determine which molecular markers provide independent prognostic information with
respect to traditional prognostic factors in these patients.
- Compare and contrast the prevalence of positivity in Native American women with breast
cancer with an age- and stage-matched cohort of Caucasian women with breast cancer
enrolled on clinical trial NCCTG-77-30-51 or the Mayo Breast Cancer Registry.
OUTLINE: Immunohistochemistry is performed on tumor samples to analyze the following
molecular markers: estrogen receptor, progesterone receptor, c-erbB2, p53, Ki-67, Bcl-2,
Bax, cyclin D-1, and insulin-like growth factor-1R.
;
Observational Model: Case-Only, Time Perspective: Prospective
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