Breast Cancer Clinical Trial
Official title:
Molecular Detection of Circulating Cancer Cells in Breast, Ovarian, Colon and Pancreatic Cancer
RATIONALE: Counting the number of circulating cancer cells in samples of blood from patients
with metastatic cancer may help doctors find out how much the cancer has spread.
PURPOSE: This research study is looking at the number of circulating cancer cells in
patients with metastatic breast cancer, ovarian cancer, colon cancer, or pancreatic cancer.
OBJECTIVES:
- To assess frequency of circulating tumor cells (CTCs) in patients with metastatic
ovarian, breast, pancreatic, and colon cancers.
- To assess the variability in number of CTCs between patients with the same tumor type.
- To correlate the number of CTCs with extent of tumor burden as measured by tumor
markers, imaging, and the number of metastatic sites and proliferation and apoptotic
markers.
OUTLINE: Blood samples are collected before treatment and analyzed using molecular detection
techniques to detect circulating cancer cells. Samples are assessed by immunofluorescence
for markers of proliferation and survival (e.g., EGFR, phosphorylated EGFR, AKT,
phosphorylated AKT, cytokeratins, MAPK, Src, and FAK).
;
Observational Model: Cohort, Time Perspective: Prospective
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