Breast Cancer Clinical Trial
Official title:
Determination Of FEZ1/LZTS1 Expression As A Predictor Of Response To Taxol
RATIONALE: DNA analysis of tumor tissue may help doctors predict how patients who receive
paclitaxel will respond to treatment.
PURPOSE: This laboratory study is evaluating gene expression in predicting response to
paclitaxel in patients with breast cancer.
OBJECTIVES:
- Determine whether loss of function of the FEZ1/LZTS1 gene is a predictor of response in
patients with breast cancer treated with paclitaxel.
OUTLINE: This is a single-blind study.
Tumor tissue is analyzed for FEZ1/LZTS1 gene expression by immunohistochemistry using an
antibody for the gene. Tumor expression of the gene is characterized by immunohistochemistry
and scored by intensity of staining, percent of cell staining, and staining index. Tumor
tissue is also analyzed for FEZ1/LZTS1 gene disruption by reverse transcriptase-polymerase
chain reaction and direct sequencing.
PROJECTED ACCRUAL: Approximately 120 patients will be accrued for this study.
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