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Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer

Breast Cancer Clinical Trial

Official title:
A Randomized, Prospective Trial of 2-6 Weeks Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer: Anastrozole +/- Fulvestrant or Tamoxifen Exposure - Response in Molecular Profile (AFTER-study).

Clinical Trial Summary

To investigate prospectively whether short term endocrine treatment can induce molecular changes, predictive for therapy response.

Clinical Trial Description

We will perform a randomized, open-label, single-institution study. It will compare the efficacy of three different endocrine treatment regimens (Anastrozole +/- Fulvestrant or Tamoxifen) in changing proliferation-index and inducing apoptosis during a 2-6 week pre-operative treatment period in breast cancer patients. These results will be correlated to gene expression profiles, phosphorylation status of the ER, SNPs in CYP450 sequences, tamoxifen metabolite concentrations, changes in estrogen serum levels and protein expression patterns. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00738777
Study type Interventional
Source The Netherlands Cancer Institute
Contact
Status Suspended
Phase Phase 2
Start date July 2008
Completion date June 2024
View Details
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