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Short-term Presurgical Study to Assess Molecular Predictors of Lapatinib's Effects in Primary Breast Cancer — MAPLE  

Breast Cancer Clinical Trial

Official title:
A Double Blind Short-Term Presurgical Study Assessing the Molecular Antiproliferative Predictors of Lapatinib's Effects in Breast Cancer

Clinical Trial Summary

To provide an in vivo measure of the activity of lapatinib. To assess the antiproliferative effects of lapatinib in breast cancer, ie how much lapatinib slows down the growth of cancer cells by measuring K167 (a marker of proliferation) in breast tumours before and after a short treatment with lapatinib.

Clinical Trial Description

Randomised multi centre double blind pre-surgical study in women with a histological diagnosis of breast cancer by core biopsy. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00299286
Study type Interventional
Source Institute of Cancer Research, United Kingdom
Contact
Status Completed
Phase Phase 2
Start date June 2007
Completion date August 2011
View Details
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