Breast Cancer Clinical Trial
Official title:
Phase II Evaluation of Docetaxel Combined With Estramustine Phosphate in Patients With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of docetaxel combined with estramustine
in treating women with metastatic breast cancer.
OBJECTIVES: I. Determine the response rate, duration of response, duration of survival, and
quality of life effects of docetaxel and estramustine combination in women with metastatic
breast cancer.
OUTLINE: Patients receive estramustine 3 times a day for 3 days. Docetaxel begins on day 3
after the a.m. dose of estramustine and is given as a 1 hour infusion intravenously. Courses
repeat every 21 days. If disease responds or is stable, treatment continues at the highest
tolerance percentage of prescribed dose until appearance of disease progression. If complete
response is documented, an additional 2 courses are given. Patients should receive a minimum
of 2 courses unless rapid progression or unacceptable toxicity occur. Patients are followed
monthly.
PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study.
;
Primary Purpose: Treatment
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