Breast Cancer Clinical Trial
Official title:
A Radomized Trial of Epirubicin & Cyclophosphamide vs. Epirubicin & Paclitaxel in the Treatment of Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Randomized phase III trial to compare the effectiveness of epirubicin and
cyclophosphamide with epirubicin and paclitaxel in treating women with metastatic breast
cancer.
OBJECTIVES: I. Compare the activity and toxicity of epirubicin and cyclophosphamide with
that of epirubicin and paclitaxel in patients with metastatic breast cancer.
OUTLINE: Patients are randomized to receive either epirubicin and cyclophosphamide or
epirubicin and paclitaxel. Each drug combination is given every 3 weeks for 6 courses in the
absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 704 patients will be accrued for this study.
;
Primary Purpose: Treatment
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