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99mTc-DARPinG3 SPECT/CT for Non-invasive HER2-AX in Breast Cancer With Metastatic Lymph Nodes Before Targeted Therapy

Breast Cancer Female Clinical Trial

Official title:
SPECT/CT Imaging of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Primary Tumour and Metastatic Axillary Lymph Nodes Using Technetium-99m-labelled DARPinG3 Molecule-based.

Clinical Trial Summary

An open-label, single center study with 99mTc-DARPinG3 SPECT/CT and biopsies of primary tumour and metastatic lymph nodes in breast cancer patients, where the primary endpoint of the study is to find out the correlation between the HER2 expression measured by 99mTc-DARPinG3 SPECT/CT and standard histopathology from relevant tumor and lymph node biopsies.

Clinical Trial Description

Overall goal of the project: To determine HER2 expression level in primary breast cancer and axillary lymph node metastases before chemo/targeted therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05695859
Study type Observational
Source Tomsk National Research Medical Center of the Russian Academy of Sciences
Contact
Status Completed
Phase
Start date December 20, 2022
Completion date December 1, 2023
View Details
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