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Breast clinical trials

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NCT ID: NCT06162351 Recruiting - Cancer Clinical Trials

A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer

TOPOLOGY
Start date: April 17, 2024
Phase: Phase 2
Study type: Interventional

Single arm phase II study for with primary objective to evaluate the efficacy of PLX038 on response rate for patients with pretreated, metastatic or locally advanced triple negative breast cancer.

NCT ID: NCT06157879 Recruiting - Healthy Clinical Trials

Measuring Electrical Properties of Breast Tissues

Start date: May 27, 2024
Phase: N/A
Study type: Interventional

The goal of this observational study is to use a low-powered microwave imaging system to provide insight into the correlation of electrical properties of breast tissue at microwave frequencies and breast density obtained from mammograms in healthy women between the ages of 18 and 74. The main questions it aims to answer : • Is there a correlation between the electrical properties of breast tissue and breast density obtained from mammograms? Both breasts of each participant will be scanned by the microwave imaging system six times in total.

NCT ID: NCT06083415 Recruiting - Clinical trials for Environmental Exposure

Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context

PENELOPE
Start date: May 15, 2023
Phase: N/A
Study type: Interventional

Various studies show an increase in the number of cases of early puberty in girls with breast development with a variable clinical presentation and evolution. This increasing phenomenon concerns girls between 6 and 8 years old. In a large number of cases, from 70 to 95% depending on the series, no medical cause is found and environmental factors are suspected to be involved. Descriptive studies of these patients are scarce and not always provide an overview of all the parameters in line with the concept of the exposome. The PENELOPE clinical trial will allow to analyze a large number of parameters, including the adipose tissue, its metabolism, the endocrine disruptors, and the epigenetic modifications, and to study the impact of environmental health measures in the evolution of these parameters. The data from the analyses of the endocrine disruptors of the patients will be explored in parallel in experimental models (amphibians, murine, cellular) in order to test potential mechanistic hypotheses.

NCT ID: NCT05720039 Recruiting - Breast Cancer Clinical Trials

Robotic vs. Open NSM for Early Stage Breast Cancer

SP NSM
Start date: May 8, 2023
Phase: N/A
Study type: Interventional

This study evaluates the safety and effectiveness of the da Vinci SP Surgical System compared to Open NSM in Nipple Sparing Mastectomy procedures.

NCT ID: NCT05663801 Not yet recruiting - Cancer Clinical Trials

Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy

Start date: February 2023
Phase: Phase 2
Study type: Interventional

There are no published article that compare magnesium sulfate and ketamine as adjuvants to bupivacaine in PECS block , so the aim of this study is to evaluate the efficacy of Magnesium sulfate versus ketamine when added to local anesthetic ( Bupivacaine) in pectoral nerve block during mastectomy and detect which of these drugs has the more effective analgesic effect and decrease opioid consumption .

NCT ID: NCT05290402 Recruiting - Breast Clinical Trials

Development of an Application-Based Digital Navigator for Perioperative Breast Surgery Patients

Start date: February 28, 2022
Phase:
Study type: Observational

The goal of this research study is to learn how accessible JEEVA is for patients during the perioperative period (the time after the pre-operative surgical appointment, and up to 30 days after surgery

NCT ID: NCT05016310 Active, not recruiting - Breast Cancer Clinical Trials

A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation

Start date: September 16, 2021
Phase: N/A
Study type: Interventional

This is a randomized study evaluating the effects of early intensive vitamin D supplementation compared to standard of care vitamin D supplementation on bone health over an 18 month period.

NCT ID: NCT04715802 Active, not recruiting - Clinical trials for Breast Reconstruction

Options on the Breast Reconstruction Timing and Method After Removal of Polyacrylamide Hydrogel

Start date: October 18, 2006
Phase:
Study type: Observational

Since polyacrylamide hydrogel (PAAG) was used in cosmetic surgery in 1997, about 30 million women have received PAAG injection for breast augmentation. Although the use of PAAG has been prohibited in most countries due to its myriad complications, a large number of symptomatic patients and asymptomatic patients have continued to seek medical advice. The strategy of repairing secondary breast deformities after PAAG removal has increasingly become a concern for both doctors and patients, but there is no standardized algorithm yet. The purpose of the present study was to perform a retrospective study to compare the safety and effectiveness of different reconstruction timing and method after removing the gel.

NCT ID: NCT04524728 Completed - Neoplasm Malignant Clinical Trials

Patterns of Treatment and Outcome of Palbociclib Plus Endocrine Therapy

Start date: December 2016
Phase:
Study type: Observational [Patient Registry]

This is a multicentre real-world experience aimed at verifying the outcome of palbociclib plus ET in an unselected population of MBC patients. The primary endpoint is the clinical benefit rate (CBR); secondary aims are the median PFS (mPFS), overall survival (OS) and safety.

NCT ID: NCT04333706 Recruiting - Cancer Clinical Trials

A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)

EMPOWER
Start date: September 26, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This study looks to advance a novel and potent strategy to eliminate minimal residual disease (MRD) in triple negative breast cancer (TNBC) present even after multimodal treatment, thereby improving survival and increasing cure rate in this aggressive cancer. Patients with locally advanced TNBC are at high risk of developing lethal metastatic disease within 2 years of diagnosis, especially for those without a pathologic complete response (pCR) after neoadjuvant chemotherapy. The high risk occurs despite surgical excision of the primary tumor and axillary lymph nodes to eliminate residual disease.