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Brain Metastases, Adult clinical trials

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NCT ID: NCT04397978 Recruiting - Clinical trials for Brain Metastases, Adult

Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

LAT-MUM
Start date: October 10, 2020
Phase:
Study type: Observational [Patient Registry]

To observe the quality of life (QOL) and to report on toxicity and outcome parameters after the (repeated) use of local ablative therapy (LAT) i.e. stereotactic radiotherapy (SRT) for patients with multiple (4-10) brain metastases

NCT ID: NCT04396717 Recruiting - Clinical trials for Brain Metastases, Adult

Safety Study of Pritumumab in Brain Cancer

Start date: March 18, 2021
Phase: Phase 1
Study type: Interventional

Pritumumab is a human IgG1 kappa antibody that binds to a malignant tumor associated antigen, ecto domain-vimentin (EDV) which is expressed in a variety of tumor cells. Pritumumab was shown to have relatively high reactivity with brain cancer cell lines, while no reactivity was demonstrated with normal neurons, astrocytes or fetal cerebral cells. Pritumumab has notable antibody-dependent cellular cytotoxicity (ADCC), brain tumor penetration and antitumor activity in nude mouse human xenograft models. Primary Objectives - To determine the safety and/or tolerability and the recommended Phase 2 dose (RP2D) of escalating, intravenously (IV) administered Pritumumab doses in patients with recurrent gliomas or with brain metastases. Secondary Objectives - To determine pharmacokinetics and pharmacodynamics of Pritumumab - To identify preliminary signals of anti-tumor response to Pritumumab - To explore disease-related, patient-reported outcomes

NCT ID: NCT04343157 Recruiting - Cancer Clinical Trials

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

IG-SRS
Start date: May 1, 2019
Phase: Phase 2
Study type: Interventional

In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.

NCT ID: NCT04197297 Recruiting - Clinical trials for Brain Metastases, Adult

Brain Imaging Biomarkers in Patients With Brain Metastasis

Start date: October 5, 2021
Phase: Phase 2
Study type: Interventional

A biomarker is a measurable indicator of the severity or presence of some disease state. In this study, brain metastases patients who will be receiving radiation treatment, will undergo CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) scans prior to and after radiation treatment to measure these biomarkers. This is a single-center phase II study to validate the predictive abilities of biomarkers, in terms of determining how patients will respond to radiation treatment.