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Clinical Trial Summary

Staphyloccous aureus and coagulase negative staphylocci are responsible of a large marjority of PJI. Regarding the high rate of methicillin resistance, current guidelines recommend the use of a glycopeptide, and most frequently vancomycin, as the anti-gram positive agent in empirical therapy, while awaiting the microbiological results. Vancomycin is not considered as a safe antibiotic, and daptomycin is frequently an alternative option.

Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. As some data report a synergistic activity with daptomycin, they could be an option in pandrug-resistant staphylococci BJI, but their use if off label in this indication.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04409769
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Completed
Phase
Start date February 1, 2020
Completion date May 5, 2020

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