Bone and Joint Infection Clinical Trial
Official title:
Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine
Optimal surgical therapy (debridement in chronic osteomyelitis; device exchange in patients with chronic prosthetic joint infection [PJI]) could be sometimes non-feasible, especially in the elderly population. Therefore, a medical therapy with oral prolonged suppressive antibiotic therapy (PSAT) seems to be an option to prevent recurrence and prosthesis loosening. Unfortunately, some patients are infected with resistant pathogens for which oral antibiotics are not suitable. Subcutaneous (SC) administration of injectable intravenous antibiotics as PSAT could be a convenient way to limit catheter-related complications and facilitate ambulatory care. However, there are few data concerning the development of resistance under subcutaneous prolonged treatment with betalactamine. The aim of this study is is just to constitute a biological collection from samples from the GUT microbiote in patients having a bone or joint infection treated by a suppressive subcutaneous antibiotherapy with betalactamine. Later analysis will be led on those samples to detect the acquisition of resistance or not.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05421312 -
Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip
|
Phase 4 | |
| Active, not recruiting |
NCT04563325 -
Oral-only Antibiotics for Bone and Joint Infections in Children
|
Phase 4 | |
| Completed |
NCT03627000 -
Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
|
||
| Completed |
NCT03311113 -
Adherence to Oral Antibiotics In Patients With Osteoarticular Infections
|
||
| Recruiting |
NCT05753215 -
Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection
|
Phase 2 | |
| Completed |
NCT03209921 -
Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections
|
N/A | |
| Completed |
NCT04418882 -
Septic Management and Outcome of Open Fracture
|
||
| Completed |
NCT05248490 -
Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home
|
N/A | |
| Completed |
NCT03624855 -
Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France
|
||
| Recruiting |
NCT04496024 -
Ofloxacin Concentration-toxicity Relationship in the Elderly
|
N/A | |
| Recruiting |
NCT04933344 -
Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infections
|
||
| Recruiting |
NCT04538053 -
BonE and Joint Infections - Simplifying Treatment in Children Trial
|
Phase 4 | |
| Completed |
NCT04373278 -
Infection After Free Fibula Flap Reconstruction of the Mandible: a Retrospective Cohort Study
|
||
| Completed |
NCT03209934 -
Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center
|
N/A | |
| Recruiting |
NCT02817711 -
Lyon BJI Cohort Study
|
N/A | |
| Completed |
NCT03177369 -
Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration
|
N/A | |
| Recruiting |
NCT04722926 -
Lyon PJI Retrospective Cohort Study
|
||
| Completed |
NCT03852784 -
Osteoarticular Infections With Pneumococcal
|
||
| Recruiting |
NCT03796104 -
Prognostic Impact of Delta-haemolysin Production Deficiency in Staphylococcus Aureus on the Prognosis of Infected Implant Treated by DAIR
|
||
| Completed |
NCT03848104 -
Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections
|