Bone and Joint Infection Clinical Trial
Official title:
Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections
Daptomycin is a cyclic lipopeptide that has been proposed as an alternative therapeutic
option in patients with prosthetic joint infection caused by Staphylococcus or Enterococcus
species in the latest Infectious Diseases Society of America (IDSA) guidelines.
The population pharmacokinetics (PK) of daptomycin have been described in various groups of
patients in previous publications. However, little information exists on the PK of daptomycin
in patients with bone and joint infections (BJI). Also, previous population studies did not
investigate daptomycin PK over prolonged therapy, and, to our knowledge, no study has
reported the intraindividual PK variability of this drug.
The aim of this study is to describe the inter- and intraindividual PK variability of this
drug.
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