Bipolar Disorder Clinical Trial
Official title:
Treatment Resistant Depression in Bipolar Disorder - A Randomized Controlled Trial of Electroconvulsive Therapy
This project is a randomized controlled trial of electroconvulsive therapy (ECT) compared to treatment as usual (TAU) in the treatment of treatment resistant depression (TRD) in bipolar disorder. The purpose of the trial is to document the effect size, relative effect size and adverse effects of ECT in this condition. A specific purpose is to gain more knowledge about the effect on cognitive function.
This project is a randomized controlled trial of electroconvulsive therapy (ECT) compared to
treatment as usual (TAU) in the treatment of treatment resistant depression (TRD) in bipolar
disorder. The purpose of the trial is to document the effect size, relative effect size and
adverse effects of ECT in this condition. A specific purpose is to gain more knowledge about
the effect on cognitive function.
In a national collaboration project the investigators will compare the antidepressant and
cognitive effects of ECT with the effects of a drug treatment in use for this condition; a
treatment algorithm combining antidepressants, mood stabilizer and antipsychotic drugs. The
investigators will use a neuropsychological test battery to disclose possible ECT induced
changes in cognitive function, and investigate any long-lasting changes.
In addition, several studies have implemented inflammatory processes in the pathogenesis of
depression; inflammatory processes will be examined as a function of changes in clinical
status and of treatment modality.
The study is a national collaboration, using the Bipolar Research And Innovation Network-
BRAIN, and all the patients are included in the BRAIN-study. The study is funded by Helse
Vest RHF, Regional research network on mood disorders (MoodNet) and Norwegian hospitals.
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