Atherosclerotic Heart Disease With Angina Nos Clinical Trial
Official title:
Effect of Hypercholesterolemia Alone or Combined With Hypertension on the Degree of Coronary Artery Stenosis in Patients With Coronary Heart Disease Angina Pectoris: a Retrospective Study
A multicenter, retrospective clinical study was carried out in the medical records management system of 6 hospitals in Tianjin. Patients who were suffered with Coronary heart disease angina pectoris and underwent coronary angiography are collected. The investigators collect and analyze the demographics, laboratory information, clinical outcome data, and coronary angiographic data of patients. To explore the correlation between hypercholesterolemia and the degree of coronary artery stenosis of Coronary heart disease angina pectoris, and to further research the influence of hypertension on total cholesterol level and coronary artery stenosis, and provide guidance for clinical prevention and treatment.
Based on the total cholesterol level, the investigators divided patients into 3 groups:
patients with TC < 5.18 mmol/l belong to normal TC (NTC) group, 5.18 ≤ TC < 6.19 mmol/l is
borderline-high TC (BHTC) group, those with TC ≥6.19 mmol/l belong to high TC (HTC) group,
and the correlation between the TC and the degree of coronary artery stenosis is evaluated.
With or without hypertension will be further stratified to assess the effect of with or
without hypertension on the correlation between TC levels and the degree of coronary artery
stenosis. The 6 subgroups are: NTC/-HTN group, NTC/+HTN group, BHTC/-HTN group, BHTC/+HTN
group, HTC/-HTN group, HTC/+HTN group.
The investigators refer to the recent diagnostic guidelines for coronary heart disease angina
pectoris at home and abroad. The diagnosis can be given if it meets any one or more of the
following:
1. There was a clear history of old myocardial infarction.
2. Previous coronary angiography or coronary CTA examination showed that at least one major
branch of coronary artery has a lumen diameter stenosis ≥50%.
3. Those with ST-segment depression or T-wave inversion on ECG after coronary
revascularization.
The investigators will redefined hypertension as systolic blood pressure ≥130 mmHg or
diastolic blood pressure ≥80 mmHg according to the recently published 2017 ACC/AHA
guidelines.
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