Atherosclerosis Clinical Trial
Official title:
Visceral Abdominal Fat, Non Alcoholic Fatty Liver Diseases and Asymptomatic Coronary Atherosclerosis
Visceral fat or peri-omental fat is increasingly associated with metabolic syndrome, a
condition carrying a high risk of coronary artery disease. The independent role of Visceral
Fat in cardiovascular risk remains unclear.
Patients with excess of visceral fat and NAFLD patients will have higher prevalence of
coronary atherosclerosis plaques independently by metabolic syndrome diagnosis. Suggesting
that the presence of visceral fat and/or fatty liver will be considered an important
condition to optimize the cardiovascular risk stratification
Abstract Background: Visceral fat or peri-omental fat is increasingly associated with
metabolic syndrome, a condition carrying a high risk of coronary artery disease. The
independent role of Visceral Fat in cardiovascular risk remains unclear. Aim: Evaluate the
relationship between visceral fat, fatty liver and asymptomatic coronary atherosclerosis in
patients with the major cardiovascular risk factors and with or without metabolic syndrome.
Methods: 50 patients (age 53±7) with excess of visceral fat visceral, 30 patients with NAFLD
and 30 sex, age matched individuals without NAFLD will be recruited . All will be
asymptomatic for cardiac related symptoms. Subjects with clinical history of ischemic heart
disease, cerebrovascular disease, renal failure, cancer and allergy to lode will be
excluded. Coronary artery disease (CAD) will be defined as coronary plaques, with
obstructive (70%) or non obstructive lesions (30%). Degree of fatty infiltration
(ultrasound), Visceral fat amount (CT), coronary plaques and stenosis (coronary computed
tomography angiography,CCTA), markers of insulin resistance,lipotoxicity, systemic
inflammation, and oxidant-antioxidant status will be measured measured.
Expected Results: Patients with excess of visceral fat and patients with NAFLD will have
higher prevalence of coronary plaques and higher prevalence of non obstructive coronary
stenosis, higher HOMA CRP, and TG serum levels than controls. In patients with excess of
visceral fat , more segments with atherosclerosis per patient will be detected . Multiple
regression analysis is expected to show that visceral fat and fatty liver are strong
predictors of coronary atherosclerosis independently by metabolic syndrome diagnosis and
independently by markers of insulin resistance, lipotoxicity and inflammation.
Conclusion: Patients with excess of visceral fat and NAFLD patients will have higher
prevalence of coronary atherosclerosis plaques independently by metabolic syndrome
diagnosis. Suggesting that the presence of visceral fat and/or fatty liver will be
considered an important condition to optimize the cardiovascular risk stratification.
;
Observational Model: Cohort, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05052918 -
The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
|
N/A | |
Recruiting |
NCT04511234 -
Sirolimus Coated Balloon Versus Standard Balloon for SFA and Popliteal Artery Disease
|
N/A | |
Completed |
NCT05906797 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
|
N/A | |
Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
Suspended |
NCT02932176 -
Machine Learning for Handheld Vascular Studies
|
||
Recruiting |
NCT05158257 -
Clinical Of Plain Balloon Dilatation Combined Stent Versus Endovascular Debulking Combined Drug-coated Balloon to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
|
N/A | |
Completed |
NCT01212900 -
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
|
Phase 4 | |
Completed |
NCT03697382 -
Effect of Daily Steps on Fat Metabolism
|
N/A | |
Recruiting |
NCT06230406 -
T-Mem GEne in Atherosclerosis
|
||
Completed |
NCT03654313 -
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
|
Phase 1 | |
Completed |
NCT00382564 -
Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease
|
N/A | |
Recruiting |
NCT02894931 -
Effects of Dietary Interventions on Serum and Macrophage Atherogenicity
|
N/A | |
Not yet recruiting |
NCT02578355 -
National Plaque Registry and Database
|
N/A | |
Completed |
NCT02998918 -
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
|
N/A | |
Recruiting |
NCT02265250 -
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
|
||
Completed |
NCT02224339 -
New Technologies to Determine Carotid Plaque Vulnerability
|
||
Completed |
NCT03393377 -
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
|
N/A | |
Completed |
NCT02268513 -
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study
|
||
Completed |
NCT02377310 -
Pd/Pa vs iFRâ„¢ in an Unselected Population Referred for Invasive Angiography
|
N/A | |
Completed |
NCT02116829 -
Is There Room for Butter in a Healthy Diet?
|
N/A |