Asthma Clinical Trial
Official title:
COVID-19 Infection and Epithelial Cell Markers
NCT number | NCT04787588 |
Other study ID # | 11033-T |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | February 14, 2021 |
Est. completion date | February 1, 2022 |
To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.
Status | Recruiting |
Enrollment | 235 |
Est. completion date | February 1, 2022 |
Est. primary completion date | December 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age 18 years and above; - Able to give informed consent; - Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g. RT-PCR) and with a positive result and clinical features in keeping with COVID-19 illness. The control group will be patients with a negative RT-PCR COVID-19 test and without any clinical features to suggest COVID-19 illness. In addition, the control group should have NO known or current features of respiratory infection, COPD, asthma, interstitial lung disease, other respiratory inflammatory conditions or lung cancer. - Able to provide a breath sample (as based on clinical judgement). Exclusion Criteria: - none |
Country | Name | City | State |
---|---|---|---|
Canada | McMaster Cardio-Respiratory Research Lab | Hamilton | Ontario |
Lead Sponsor | Collaborator |
---|---|
McMaster University |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | TSLP expression in nasal epithelium | Compare the level of TSLP expression in nasal epithelium in patients with and without COVID-19 infection | Through study completion, an average of 1 year | |
Secondary | TSLP expression in endobronchial biopsies | Epithelial cell expression (protein staining) of TSLP in endobronchial biopsy tissue of asthmatic patients versus normal controls. | Baseline | |
Secondary | IL-33 expression in endobronchial biopsies | Epithelial cell expression (protein staining) of IL-33 in endobronchial biopsy tissue of asthmatic patients versus normal controls. | Baseline | |
Secondary | ACE-2 receptor expression in endobronchial biopsies | Epithelial cell expression (protein staining) of ACE-2 receptor in endobronchial biopsy tissue of asthmatic patients versus normal controls. | Baseline |
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