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Arthritis Knee clinical trials

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NCT ID: NCT06196359 Completed - Rehabilitation Clinical Trials

Assessing Function and Pain After Total Knee Arthroplasty With Combined Femoral and Popliteal Nerve Block

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The goal of this interventional study is to examine whether a pain management technique of combined femoral and popliteal nerve block is effective in total knee arthroplasty patients. The main questions it aims to answer are: Are there differences in postoperative outcomes? Does the nerve block, age, preoperative quadriceps muscle strength and Oxford Knee Score of the patient predict early functional ability? Participants underwent total knee arthroplasty and assessments. Researchers compared pain management techniques to assess effects on postoperative outcomes and identified the importance of preoperative variables a predictors of early functional ability. Further research is required to refine postoperative pain management strategies.

NCT ID: NCT05696418 Completed - Clinical trials for Arthroplasty Complications

Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA

Start date: January 15, 2021
Phase: N/A
Study type: Interventional

Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity. Total knee arthroplasty is currently an accepted treatment for severe degenerative conditions and there are various implant systems with special features depending on component geometry, degree of fit of the articular surfaces, and fixation techniques. A tibial component with mobile polyethylene has been developed as an alternative to fixed polyethylene because it has theoretical advantages in terms of increasing the range of motion, reducing wear conditions, and reducing the incidence of anterior knee pain when the articular surface of the patella is not resurfaced.

NCT ID: NCT05691751 Completed - Blood Loss Clinical Trials

Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Tourniquet application in total knee arthroplasty has many benefits and might have a role in the incidence of peri-operative complications the aim of this research: is to look into the effectiveness of the limited application of tourniquet during primary unilateral total knee arthroplasty and compare the perioperative complications with the standard full-time application.

NCT ID: NCT05659329 Completed - Arthritis Knee Clinical Trials

Retrospective Simplex High Viscosity (HV) Bone Cement Study

Start date: April 25, 2016
Phase:
Study type: Observational

This study is a retrospective multicenter study to review the use of Simplex High Viscosity Bone Cement in Primary Total Knee Arthroplasty

NCT ID: NCT05462483 Completed - Arthritis Knee Clinical Trials

Heat Application to Quadriceps Effect on Pain After a Total Knee Arthroplasty

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

The goal of this study is to explore an under-researched aspect of recovery. Typically, post-operative care after a knee arthroplasty consists of compression (stockings), medications, rest, ice, elevation, physical therapy, and wound care. All of these treatments perform their role well, however, medications such opiates run the risk of addiction. An additional method of pain management such as heat application to the surrounding musculature warrants exploration. The goal of this study is to reduce the amount of pain, and improve the quality of life in post-operative patients. Pain, stiffness, symptoms, quality of life and function of the knee will be evaluated utilizing patient-reported measures and range of motion. Patients will be assessed using the Knee Injury and Osteoarthritis Outcome survey (KOOS Jr), Visual Analogue Scale (VAS) and PROMIS. Patients will be given these surveys during their two and six week check-in with the surgeon. In addition to these patient-reported measures, the investigators will also be tracking range of motion (ROM) and opioid usage. The data will then be collected via the patient's electronic health record, or by the researcher directly. The treatment group will be given a written order to apply heat to the quadriceps at least three times per day for 10-15 minutes each. This can be done in four hour increments or when patients symptoms begin to worsen. The patient will receive a rice sock for heat application. The control group will not be withheld from heat application, but will not be instructed to do so. The control group will instead follow the current standard of care as advised by the physician.

NCT ID: NCT05065775 Completed - Anesthesia Clinical Trials

Bioavailability of Intranasal Dexmedetomidine

INDEX
Start date: November 1, 2021
Phase: Phase 4
Study type: Interventional

Aim of this study is to characterize the pharmacokinetics of dexmedetomidine in supine, anesthetized adult patients after intranasal dosing.

NCT ID: NCT04969432 Completed - Arthritis Knee Clinical Trials

Effectiveness of Client-centered Intervention in After Total Knee Arthroplasty

Start date: January 7, 2021
Phase: N/A
Study type: Interventional

The current study was conducted to comparison of the Client-centered (CC) intervention with face-to-face (FF) and TR methods after Total Knee Arthroplasty (TKA). The pilot study was planned to examine the impact of the CC intervention on quality of life, perceived occupational performance and satisfaction. The current study was designed according to the CONSORT statement, which provides a standardized method for randomized controlled trial (RCT) design. Approval for the study was granted by the Local Ethics Committee. Written informed consent was obtained from all participants prior to the study.

NCT ID: NCT04956393 Completed - Osteoarthritis Clinical Trials

The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study

SOARPOC
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Adolescents and young adults who hurt their knees playing sports or doing recreational activities can develop joint damage, muscle weakness, inactivity, and weight gain which might lead to an increased risk of osteoarthritis (OA), a disabling joint condition in their later lives. Despite knowing that muscles and joints benefit from exercise, there is no proven exercise-based treatments to delay or even halt the onset of OA after a knee joint injury. The current study will assess if a physiotherapist-guided intervention called Stop OsteoARthritis (SOAR) improves knee muscle strength, physical inactivity, knee-related self-efficacy, and knee-related quality of life in people at risk for osteoarthritis due to a past knee injury. A total of 70 former knee injury participants will be randomly assigned to two groups. One group will immediately start a 16-week SOAR program, while the second will wait for 9-weeks before starting an 8-week SOAR program. Trained physiotherapists will deliver the SOAR program with videoconferencing. The study hypothesis is that participating in the 8-Week SOAR program will improve the knee muscle strength, physical activity levels, knee-related self-efficacy and knee-related quality of life in people discharged from regular healthcare after a sports knee injury. The findings will help researchers understand the ideal length of the program for a future clinical trial in real-world settings.

NCT ID: NCT04923724 Completed - Arthritis Knee Clinical Trials

Tourniquet on Total Knee Arthroplasty

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is determine the effect on novel pressure-regulating tourniquet use on pain, functional recovery, sleep and total blood loss following total knee arthroplasty.

NCT ID: NCT04910165 Completed - Pain, Postoperative Clinical Trials

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

Start date: June 1, 2020
Phase: Phase 3
Study type: Interventional

Exparel has been shown to have better pain control compared to previously used infiltration agents, including bupivacaine, while having a minor side effect profile. The purpose of this study is to explore the effectiveness of Exparel (liposomal bupivacaine) in Adductor Canal Blocks for peri-operative pain control following a total knee arthroplasty (TKA) procedure.