Clinical Trials Logo

Arterial Occlusive Disease clinical trials

View clinical trials related to Arterial Occlusive Disease.

Filter by:

NCT ID: NCT04275323 Recruiting - Clinical trials for Peripheral Vascular Disease

Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-1)

Start date: August 2, 2019
Phase: Phase 3
Study type: Interventional

To evaluate the safety and efficacy of recombinant human hepatocyte growth factor (HGF) bare plasmid injection for local intramuscular injection in the treatment of patients with severe lower limb hemorrhagic disease (Rutherford grade 4)

NCT ID: NCT04274049 Completed - Clinical trials for Peripheral Vascular Disease

Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-2)

Start date: August 18, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether intramuscular injections of NL003 into the calf is safe and effective in the treatment of critical limb ischemia

NCT ID: NCT02685098 Active, not recruiting - Clinical trials for Cardiovascular Disease

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

CHAMP
Start date: January 23, 2017
Phase: Phase 1
Study type: Interventional

Patients undergoing semi-elective lower extremity major amputation from complications associated with atherosclerotic limb ischemia will received intra-muscular injections of allogeneic Mesenchymal Stromal Cells in the leg above and below the point of amputation to prevent ischemic wound complications after surgery and decrease the incidence of revision and further amputation. Cohort Groups 1-4 will serve as controls.

NCT ID: NCT02255188 Completed - Clinical trials for ARTERIAL OCCLUSIVE DISEASE

Experimental Study of the Vascular Prosthesis Manufactured by Electrospinning

Start date: October 2014
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether the Vascular prosthesis manufactured by Electrospinning is safe with respect to the development of thrombosis.

NCT ID: NCT02228564 Completed - Clinical trials for Peripheral Artery Disease

BARD® Study of LIFESTREAMâ„¢ Balloon Expandable Covered Stent Treating Iliac Arterial Occlusive Disease

BOLSTER
Start date: September 2014
Phase: N/A
Study type: Interventional

Collect confirmatory evidence of the safety and effectiveness of the Balloon LIFESTREAMâ„¢ Stent Graft for the treatment of stenoses and occlusion in the iliac arteries.

NCT ID: NCT01746550 Completed - Clinical trials for Arterial Occlusive Disease

A Safety and Effectiveness Study of the MD-12-001 Stent in the Treatment of Superficial Femoral Artery or Popliteal Artery Blockages in Japanese Patients

Reliable
Start date: December 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and effectiveness of the MD-12-001 stent in the treatment of superficial femoral artery and proximal popliteal artery blockages in Japanese patients.

NCT ID: NCT01548378 Completed - Clinical trials for Peripheral Vascular Disease

Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia

NL003CLI-II
Start date: March 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate whether intramuscular injections of NL003 into the calf is safe and effective in the treatment of critical limb ischemia

NCT ID: NCT01517997 Completed - Clinical trials for Arterial Occlusive Disease

Infrapopliteal Drug Eluting Angioplasty Versus Stenting

IDEAS-I
Start date: August 2011
Phase: Phase 2/Phase 3
Study type: Interventional

In total 50 patients diagnosed with long-segment infrapopliteal arterial disease will be randomized in two groups. The patients randomized in the Drug coated balloons (DCB) study arm will undergo a percutaneous transluminal angioplasty (PTA) with the use of a paclitaxel-coated balloon, while the patients randomized in the drug-eluting stent (DES) study arm will undergo primary stenting using drug-eluting stent(s). The study's primary endpoints will be the 6-month angiographic binary restenosis rate. Secondary endpoints will include the immediate technical success,6-month primary patency, target lesion revascularization and limb salvage and complication rates.

NCT ID: NCT01002209 Withdrawn - Diabetes Clinical Trials

Postoperative Hyperbaric Oxygen Treatments to Reduce Complications in Diabetic Patients Undergoing Vascular Surgery

HODiVA
Start date: October 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This trial aims to evaluate if hyperbaric oxygen treatment (HBO) given postoperatively is effective in reducing healing time and wound complications after lower extremity bypass surgery in patients with diabetes. Hypothesis: Postoperative HBO treatment is effective in reducing complications in patients with diabetes undergoing peripheral vascular surgery

NCT ID: NCT00913900 Terminated - Vascular Diseases Clinical Trials

Safety Study of Adult Stem Cells to Treat Patients With Severe Leg Artery Disease

SCRIPT-CLI
Start date: May 2009
Phase: Phase 1
Study type: Interventional

Peripheral artery disease (PAD) due to leg artery blockages can result in painful leg muscles, skin ulcers and infection due to poor blood flow. In severe forms, the only treatment may be amputation. Adult stem cells injected into affected legs may cause new blood vessel formation and improve blood flow. The purpose of this study is to determine the feasibility and safety of injecting adult stem cells into the leg muscles of patients with severe PAD, in an attempt to improve blood flow.