Arterial Hypertension Clinical Trial
Official title:
Renal Denervation in Hypertensive Women Planning to Become Pregnant
Renal denervation is a new method to lower blood pressure (BP) in hypertensive patients by reducing the impact of sympathetic nervous system. Its efficacy has been demonstrated in resistant hypertension and in lowering BP in essential hypertension as compared to a sham procedure in untreated hypertensive patients. This procedure is safe without any serious adverse events. However its effects during pregnancy are unknown. Normal pregnancy is associated with an increase of sympathetic activity at rest and upon cardiovascular reflexes stimulation which returns to baseline after delivery. These changes maintain optimal utero placental blood flow. But excessive stimulation of sympathetic activity may play a role in preeclampsia. Drugs that may affect the sympathetic nervous system are considered as safe in pregnant women. So there are reasonable evidence that renal denervation performed before pregnancy should not have deleterious effects for the fetus. The efficiency of renal denervation being greater in young patient and in women, a greater proportion of BP normalization can be expected in this population of young women .
Investigators will include women with essential hypertension, treated or untreated, who are planning a short term pregnancy (D0). If high blood pressure is confirmed by ABPM after one month without treatment (D30), investigators will proceed to the arteriography during which they will be randomized in the renal denervation group or in the control one. After the randomization, BP monitoring by Home BP measurement will be performed every month and send to the investigator. Then the patient will benefit from a new ABPM two months after the intervention (D100), and she may stop contraception and may become pregnant. BP will be monitored during pregnancy by home BP and by a new ABPM at the beginning of the 6th month of pregnancy as well as one, one month after delivery. From the D100, the patient will be able to start an antihypertensive treatment at any time depending on HBPM or ABPM. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05684055 -
"Community-based, eHealth Supported Management of Cardiovascular Risk Factors by Lay Village Health Workers (ComBaCaL aHT TwiC 1 & ComBaCaL aHT TwiC 2)
|
N/A | |
| Active, not recruiting |
NCT05436730 -
"Escape" Phenomenon of the Antihypertensive Therapy Efficacy
|
||
| Not yet recruiting |
NCT03294070 -
Fimasartan Plus Amlodipine on Hemodynamic Parameters and Arterial Stiffness in Patients With Hypertension
|
Phase 4 | |
| Recruiting |
NCT01959997 -
Comparison of Redo PVI With vs. Without Renal Denervation for Recurrent AF After Initial PVI
|
Phase 2 | |
| Completed |
NCT00983632 -
Selective Vagus Nerve Stimulation in Human
|
N/A | |
| Recruiting |
NCT06098300 -
Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension
|
||
| Terminated |
NCT04677322 -
TO ASSESS THE EFFECTIVENESS OF THE INTERVENTION OF THE LOW-SODIUM DIET IN PATIENTS WITH HTA
|
||
| Completed |
NCT04564118 -
A Retrospective Analysis of the Adherence to Clinical Practice Guidelines Using the "MedicBK" Digital Platform in Patients With Hypertension and Atrial Fibrillation
|
||
| Completed |
NCT04278001 -
Clinical Usefullness of the Cuffless SOMNOtouch NIBP Device for 24-hour Ambulatory Blood Pressure Measurement
|
N/A | |
| Withdrawn |
NCT03047538 -
Fixed Combination for Lipid and Blood Pressure Control
|
Phase 4 | |
| Completed |
NCT03046264 -
Invasive Validation of Non-invasive Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis
|
N/A | |
| Completed |
NCT02620995 -
Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction
|
Phase 4 | |
| Completed |
NCT02041832 -
Detection of Subclinical Atrial Fibrillation in High Risk Patients Using Implantable Loop Recorder
|
N/A | |
| Completed |
NCT01459120 -
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
|
N/A | |
| Completed |
NCT01546181 -
Retinal Imaging by Adaptive Optics in Healthy Eyes and During Retinal and General Diseases
|
||
| Recruiting |
NCT01132001 -
Ambulatory Versus Home Blood Pressure Measurement
|
N/A | |
| Completed |
NCT01454583 -
Registry for Ambulant Therapy With RAS-Inhibitors in Hypertension-patients in Germany
|
N/A | |
| Recruiting |
NCT03917758 -
Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors
|
N/A | |
| Completed |
NCT03722524 -
The Use of TrIple Fixed-dose Combination in the Treatment of Arterial Hypertension
|
||
| Completed |
NCT03539627 -
Azilsartan Medoxomil in Hypertensive pAtients With Stable Ischemic Heart Disease and DiabEtes MEllitus.
|