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Characterization of the microVAScular Dysfunction in Covid-19 ARDS — VASCOV  

ARDS, Human Clinical Trial

Official title:
Characterization of the microVAScular Dysfunction in COvid-19 ARDS

Clinical Trial Summary

The primary endpoint of this research is to establish that the alveolar dead space is significantly higher in patients with COVID-19 ARDS, compared to patients with non-COVID-19 ARDS. Secondarily, the investigators want to establish the prognostic value of the alveolar-dead space (measured iteratively) in patients with COVID-19 and non-COVID-19 ARDS, to establish the respective influences of the biological parameters of endothelial damage, of the biological parameters of coagulopathy, of the parameters set on the artificial ventilator on the value of the alveolar dead space; in ARDS patients with COVID-19 and non-COVID-19 ARDS, to establish the prognostic value of the laboratory parameters of endothelial damage and coagulopathy in patients with COVID-19 and non-COVID-19 ARDS.

Clinical Trial Description

Endothelial damage and coagulation activation at the lung microvascular level may play an important role in the physiopathology of the COVID-19 ARDS. The project aims to prospectively investigate both bedside pulmonary physiological markers and biological markers of coagulopathy and endothelial dysfunction in COVID-19 and non-COVID-19 ARDS patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05074758
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact Josephine Braun, PhD
Phone 01 44 84 17 38
Email josephine.braun@aphp.fr
Status Recruiting
Phase
Start date December 10, 2021
Completion date September 10, 2022
View Details
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