Aphasia Clinical Trial - Chronic Aphasia - Improved by Intensive Training

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine if non-invasive electrical brain stimulation can enhance the outcome of intensive language therapy in chronic aphasia.

Clinical Trial Description

Stroke is the leading cause of death and disability worldwide. Given the increasing average lifespan worldwide, the incidence and prevalence of patients with stroke will dramatically increase in the future. One of the most frequent and devastating conditions after stroke is aphasia, which affects language production and comprehension. High-frequent intensive speech-and-language therapy is currently the treatment of choice in chronic aphasia. However, despite its general effectiveness, treatment effect sizes are only low to moderate. Thus, there is a pressing need to explore novel training-adjuvant therapies to enhance treatment efficacy. Moreover, very little is known about the neurobiology of treatment-induced recovery in chronic aphasia. This is the prerequisite to improve existing and/or develop new treatment paradigms.

Thus, in the present project the investigators aim to assess whether the outcome of intensive language training can be enhanced by adjuvant non-invasive brain stimulation. They will be using anodal transcranial direct current stimulation (atDCS) that has previously been shown to enhance (a) language and motor learning in healthy subjects and (b) motor recovery in stroke patients. Specifically, in a longitudinal group comparison design, two matched groups of patients with chronic anomia will receive two weeks of intensive language training with or without atDCS. Treatment effects will be assessed immediately after the two week intervention period and several months after the end of the training. The Investigators will also use functional and structural magnetic resonance imaging (MRI) to elucidate language network changes in the two groups. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01924702
Study type	Interventional
Source	Charité Neurocure AG Flöel
Contact	Robert Darkow
Phone	004930450560395
Email	robert.darkow@charite.de
Status	Recruiting
Phase	Phase 2
Start date	January 2011
Completion date	December 2015

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See also
Status	Clinical Trial	Phase
Completed	`NCT03622411` - Tablet-based Aphasia Therapy in the Chronic Phase	N/A
Recruiting	`NCT03605381` - MORbidity PRevalence Estimate In StrokE
Recruiting	`NCT03929432` - Treatment Outcomes With tDCS in Post-Stroke Aphasia	N/A
Completed	`NCT03662295` - Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention
Completed	`NCT03679637` - Tablet-based Aphasia Therapy in the Acute Phase After Stroke	N/A
Completed	`NCT03550092` - Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia	N/A
Completed	`NCT03228264` - A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.	N/A
Suspended	`NCT04290988` - Circuitry Assessment and Reinforcement Training Effects on Recovery	N/A
Recruiting	`NCT05969548` - pBFS-guided cTBS at Different Doses for Aphasia After Stroke	N/A
Recruiting	`NCT04138940` - Modulating Intensity and Dosage of Aphasia Scripts	N/A
Terminated	`NCT02249819` - Evaluating Anodal tDCS Preceding Aphasia Therapy	Phase 1/Phase 2
Completed	`NCT01654029` - Patient Centred Communication Intervention	N/A
Completed	`NCT00843427` - fMRI of Language Recovery Following Stroke in Adults	N/A
Active, not recruiting	`NCT00227461` - Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.	Phase 1
Completed	`NCT03773419` - Improving Electronic Written Communication in Aphasia	N/A
Not yet recruiting	`NCT04142866` - Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia	N/A
Suspended	`NCT04048668` - tDCS to Treat Subacute Aphasia	N/A
Recruiting	`NCT04081207` - Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia	N/A
Completed	`NCT02226796` - Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia	N/A
Completed	`NCT01163461` - Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms