Aphasia Clinical Trial - Using Augmentative & Alternative Communication to

Status Recruiting

Clinical Trial Summary

The currently available interventions only partially restore language abilities in patients with post-stroke aphasia; preventing successful reintegration into society. This study will increase our knowledge of how we can use assistive technology interventions to help people with aphasia restore language function. Further, this project will help us identify regions of the brain responsible for these changes.

Clinical Trial Description

In aphasia rehabilitation, usual care is focused on helping people recuperate as much of their pre-stroke language capacity as possible.Typically, usual care is a non-standardized therapy that is tailored to the specific needs of the person with aphasia.Once a person reaches a plateau in language recovery, AAC is implemented with a focus on circumventing, or compensating for the communication challenges associated with aphasia.

The ability of people with aphasia to (1) recover language function well-into the chronic phase of stroke recovery and (2) self-cue to promote word retrieval during anomic events offer the solution for how AAC could be employed as a dual-purpose tool to augment language recovery and compensate for deficits. This approach, however, this requires a shift in how AAC is implemented. With the goal of language recovery, treatment needs to focus on instructing people with aphasia how to use AAC as a mechanism for self-cueing, rather than as a tool to replace speaking. Based on our pilot data, we hypothesize that this novel method to AAC implementation will promote language recovery by coupling the canonical language and visual processing neural networks.

This work will also contribute to our ability to identify, a priori, who will respond to this particular AAC intervention and who will not, by combining neuroimaging with behavioral and clinical data. This has the potential to reduce the cost of healthcare for stroke recovery by implementing the most effective treatment possible. Importantly, when we identify non-responders, this will allow us to construct a profile and identify features of the AAC treatment that require adjustment to meet their unique needs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04081207
Study type	Interventional
Source	University of Cincinnati
Contact	Aimee Dietz, PhD
Phone	513-558-8551
Email	aimee.dietz@uc.edu
Status	Recruiting
Phase	N/A
Start date	September 1, 2018
Completion date	December 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03622411` - Tablet-based Aphasia Therapy in the Chronic Phase	N/A
Recruiting	`NCT03605381` - MORbidity PRevalence Estimate In StrokE
Recruiting	`NCT03929432` - Treatment Outcomes With tDCS in Post-Stroke Aphasia	N/A
Completed	`NCT03662295` - Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention
Completed	`NCT03679637` - Tablet-based Aphasia Therapy in the Acute Phase After Stroke	N/A
Completed	`NCT03550092` - Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia	N/A
Completed	`NCT03228264` - A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.	N/A
Suspended	`NCT04290988` - Circuitry Assessment and Reinforcement Training Effects on Recovery	N/A
Recruiting	`NCT05969548` - pBFS-guided cTBS at Different Doses for Aphasia After Stroke	N/A
Recruiting	`NCT04138940` - Modulating Intensity and Dosage of Aphasia Scripts	N/A
Terminated	`NCT02249819` - Evaluating Anodal tDCS Preceding Aphasia Therapy	Phase 1/Phase 2
Completed	`NCT01654029` - Patient Centred Communication Intervention	N/A
Completed	`NCT00843427` - fMRI of Language Recovery Following Stroke in Adults	N/A
Active, not recruiting	`NCT00227461` - Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.	Phase 1
Completed	`NCT03773419` - Improving Electronic Written Communication in Aphasia	N/A
Not yet recruiting	`NCT04142866` - Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia	N/A
Suspended	`NCT04048668` - tDCS to Treat Subacute Aphasia	N/A
Completed	`NCT02226796` - Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia	N/A
Completed	`NCT01163461` - Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia	N/A
Recruiting	`NCT03309930` - Narrative Comprehension by People With Acquired Brain Injury	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia — NAIL

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms