Aortic Stenosis Clinical Trial
Official title:
Risk Markers of Coronary Artery Disease Associated With Calcific Aortic Valve Disease
The purpose of this study is
- to determine the degree of endothelial dysfunction and inflammation in calcific aortic
valve disease associated with coronary artery disease(CAD).
- to determine whether there is relationship between calcium metabolism and calcific
aortic valve disease associated with CAD.
Cardiovascular disease, mainly coronary artery disease, causes more than one half of deaths
in the developed countries. Only recently, calcific aortic valve disease, was proved to
belong to the family of atherosclerosis. It is associated with higher cardiovascular
morbidity and mortality, the cause of which is not entirely clear. The link to significant
coronary artery disease, probably, is of highest importance.
We compare groups of patients with coronary artery disease and calcific stenotic, sclerotic
or intact aortic valve. The aim is to assess and compare their risk profile to verify our
hypothesis that, within significant coronary artery disease, calcific aortic valve
identifies a subgroup of patients with higher cardiovascular risk, assessed by endothelial
dysfunction and the two year follow-up of cardiovascular events on optimally set treatment.
Further, we study the possible association of valvular calcification and calcium metabolism
in patients with normal kidney function.
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Observational Model: Cohort, Time Perspective: Prospective
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