Aortic Aneurysm, Abdominal Clinical Trial
Official title:
Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation
Stroke and abdominal aortic aneurysms (AAAs) are common and highly lethal vascular diseases. Angiogenesis and infiltration of inflammatory cells such as macrophages may cause stroke and AAAs. The purpose of this study is to test PET/CT and PET/MRI imaging to specifically detect those diseases using a new developed agent (18F-FPPRGD2) that can target angiogenesis and macrophages.
20 subjects with either carotid bifurcation stenosis of >50% by ultrasound on at least one side (10 patients) or advanced AAAs (10 patients) and surgical intervention planned will be identified from physicians from the Division of Vascular Surgery at Stanford. Either a PET/CT or a PET/MRI will be performed for each subject: - PET/CT scans will be performed in 3D mode using GE Discovery 600 or GE Discovery 690 scanners (GE Healthcare). - PET/MRI scans will be performed using the novel PET/MRI system at Stanford, including a sensitive PET time-of-flight (TOF) scanner with an advanced 3T MRI scanner. The study patients will receive an intravenous administration of 10mCi of the prescribed radiotracer (18F-FPPRGD2). PET/CT or PET/MRI images will be obtained starting 45-60 minutes after radiotracer administration. For PET/CT, each image acquisition will begin with a non-contrast CT scan obtained from the vertex through the mid-thighs of the subjects. For PET/MRI, non-contrast images of the carotid or aorta will be performed. PET imaging will follow. Patient's vital signs will be monitored during the procedure and a physician will be available if there is need for immediate medical attention. The PET images will be reconstructed with a standard iterative algorithm using GE software release 5.0. After the planned surgery, we will also assess the histopathological correlation between the disease lesions and PET/CT or PET/MRI imaging characteristics. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03657979 -
TAP-Block in Abdominal Aortic Surgery
|
Phase 4 | |
Enrolling by invitation |
NCT01465425 -
Extracolonic Findings on Computed Tomography (CT) Colonography
|
||
Completed |
NCT02845167 -
Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients: Pilot Study
|
N/A | |
Not yet recruiting |
NCT00358085 -
NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study
|
Phase 3 | |
Terminated |
NCT00118573 -
Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair
|
Phase 4 | |
Completed |
NCT04792411 -
Adherence and Acceptability of a Remote, Home-based, Pre-surgery Programme for Patients Undergoing Abdominal Aortic Aneurysm Surgery
|
N/A | |
Completed |
NCT04930172 -
TOtal tRansfemoral branCHed endovasCular tHoracoabdominal Aortic Repair Registry
|
||
Completed |
NCT01980901 -
Post-Approval Study of the Ovation™/Ovation Prime™ Abdominal Stent Graft System
|
||
Active, not recruiting |
NCT01698671 -
InterGard Synergy Post-Marketing Surveillance Study
|
N/A | |
Enrolling by invitation |
NCT00831870 -
EndoSure Sensor for Long-term Follow-up After Endovascular AAA Repair
|
N/A | |
Recruiting |
NCT05972018 -
Liposomal Bupivacaine/Bupivacaine in RS Blocks vs. Ropivacaine in RS Blocks And Catheters
|
Phase 4 | |
Not yet recruiting |
NCT02997618 -
The AAA Get Fit Trial: A Pilot Randomised Controlled Trial of Community Based Exercise in Patients With Abdominal Aortic Aneurysms
|
N/A | |
Active, not recruiting |
NCT02907762 -
Aorfix Intelliflex First in Human Study
|
||
Completed |
NCT00349947 -
Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms
|
Phase 1 | |
Completed |
NCT04080557 -
Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
|
||
Recruiting |
NCT05484115 -
Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck
|
N/A | |
Recruiting |
NCT04503395 -
ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES
|
N/A | |
Completed |
NCT02867501 -
Venous Distension in Patients With Aneurysmatic Arterial Disease
|
N/A | |
Recruiting |
NCT02345590 -
Eplerenone in the Management of Abdominal Aortic Aneurysms
|
Phase 4 | |
Recruiting |
NCT01985906 -
Safety and Efficacy of Multiple Overlapping Uncovered Stents for Pararenal Aortic Aneurysm Repair
|
N/A |