Clinical Trials Logo

Clinical Trial Summary

Rupture of abdominal aortic aneurysms(AAA) causes 12,000 deaths/year in the UK.1 Elective repair to prevent this carries a perioperative mortality of 4.5% for open surgery and 1% for endovascular repair. This risk is associated with poor cardiorespiratory fitness which can be measured using Cardiopulmonary Exercise Testing(CPET) with the CPET variables, peak oxygen uptake(peakVO2)<15ml/kg/min and anaerobic threshold(AT)<10.2ml/kg/min identifying patients at increased risk of early death after AAA repair.3 These variables can therefore be used as surrogate markers for cardiovascular fitness and risk of mortality and morbidity in AAA surgery; optimising these markers should improve fitness and decrease this risk. The optimal duration and type of exercise training for improving peak VO2 and AT in AAA patients is not known. AAA patients are unique as they are motivated to reduce the risk of impending surgery but are afforded the time to improve their fitness as repair may not be needed for months or even years.

The investigators propose a pilot randomised controlled trial to explore the effectiveness of a 20-week community (either home or gym-based) exercise programme to achieve sustained improvements in peak VO2 and AT, as measured by CPET, in AAA patients. Changes in QoL, habitual activity levels and cardiovascular risk will also be assessed. The results will inform a definitive multicentre clinical trial on exercise to improve outcomes in elderly patients with cardiovascular disease and AAA.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT02997618
Study type Interventional
Source University of Manchester
Contact Adam Haque, MBChB, MRCS
Phone 01612915848
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date November 2018
Completion date April 2019

See also
  Status Clinical Trial Phase
Completed NCT03657979 - TAP-Block in Abdominal Aortic Surgery Phase 4
Enrolling by invitation NCT01465425 - Extracolonic Findings on Computed Tomography (CT) Colonography
Completed NCT02845167 - Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients: Pilot Study N/A
Not yet recruiting NCT00358085 - NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Phase 3
Terminated NCT00118573 - Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Phase 4
Withdrawn NCT02995642 - Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Phase 2
Completed NCT01980901 - Post-Approval Study of the Ovation™/Ovation Prime™ Abdominal Stent Graft System
Active, not recruiting NCT01698671 - InterGard Synergy Post-Marketing Surveillance Study N/A
Enrolling by invitation NCT00831870 - EndoSure Sensor for Long-term Follow-up After Endovascular AAA Repair N/A
Active, not recruiting NCT02907762 - Aorfix Intelliflex First in Human Study N/A
Completed NCT00349947 - Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms Phase 1
Completed NCT04080557 - Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
Recruiting NCT04503395 - ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES Phase 4
Completed NCT02867501 - Venous Distension in Patients With Aneurysmatic Arterial Disease N/A
Recruiting NCT02345590 - Eplerenone in the Management of Abdominal Aortic Aneurysms Phase 4
Recruiting NCT01985906 - Safety and Efficacy of Multiple Overlapping Uncovered Stents for Pararenal Aortic Aneurysm Repair N/A
Completed NCT00615069 - Study of the Large Diameter GORE EXCLUDER® AAA Endoprosthesis in Abdominal Aneurysms Phase 2
Completed NCT00538967 - The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm Phase 2
Active, not recruiting NCT04935268 - Demographic Differences in Patients With Abdominal Aortic Aneurysm and Surgical Features of Treatment
Completed NCT02949297 - Expanding Patient Applicability With Polymer Sealing Ovation Alto Stent Graft IDE (Investigational Device Exemption) Study N/A