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Antiretroviral Treatment clinical trials

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NCT ID: NCT04480554 Recruiting - Inflammation Clinical Trials

Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1

AMOHI-1
Start date: January 30, 2023
Phase: Phase 2
Study type: Interventional

HIV infection, as well as exposure to opioids (including heroin), are associated with systemic immune activation including increased microbial translocation from the gut. The overall objective of this study is to define the impact of long-term mu-opiate receptor stimulation or blockage with medication for opiate use disorder (i.e, methadone, buprenorphine/naloxone, or extended-release naltrexone) on the kinetics and extent of immune reconstitution on HIV-1 infected people who inject opiate and initiating antiretroviral therapy.

NCT ID: NCT03825523 Recruiting - HIV/AIDS Clinical Trials

Immediate ART in Subjects With Opportunistic Diseases

Start date: February 18, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to compare the clinical response and mortality rate by an opportunistic disease in HIV-infected individuals who start immediate versus conventional antiretroviral therapy. Immediate ART (iART) is defined as starting antiretroviral therapy in the first 48 hours after the hospitalization. Conventional ART (cART) is defined as starting antiretroviral therapy once the opportunistic infection is under control at the discretion of infectious disease specialist.

NCT ID: NCT00216359 Active, not recruiting - HIV Infections Clinical Trials

Cohort Study for Patients Using Fuzeon (Enfuvirtide)

Start date: May 2003
Phase: N/A
Study type: Observational

The Radata-Fuzeon cohort is an observational cohort study to gain a better understanding of Fuzeon (Enfuvirtide) in daily clinical practice. Patients planned to take this drug in a new antiretroviral combination therapy (ART) are eligible to participate in this observation. Physicians may register patients online via the internet. They are offered to get an expert advice suggesting therapeutics for a new ART. Observation interval is every three month. However physicians are allowed to initiate new diagnostics, expert advice and therapeutic changes independently from these intervals if necessary. Total observation time for each patients is planned for two years.