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Aneurysm, Dissecting clinical trials

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NCT ID: NCT05798754 Not yet recruiting - Clinical trials for Thoracic Epidural Space Identification

Efficacy of CompuFlo® Technology in Thoracic Epidural Space Identification

Start date: April 2023
Phase: N/A
Study type: Interventional

The aim of this non inferiority trial is to assess the efficacy of CompuFlo® technology to identify the thoracic epidural space in relation to the gold standard loss of resistance technique.

NCT ID: NCT05745428 Active, not recruiting - Aortic Dissection Clinical Trials

Shear Stress Endothelial/Hemodynamics in Aortic Dissection and Endothelial Shear Stress-biological Profile

HADES-BP
Start date: April 10, 2022
Phase:
Study type: Observational

Aortic dissection (AD) is a clinical condition belonging to the broader spectrum of Acute Aortic Syndromes, with high morbidity and mortality and characterised by the sudden formation of a breach within the tonaca intima of the aortic wall, from which the so-called false lumen originates.The most common risk factor for AD is hypertension, present in more than 70% of. Imaging, biomarkers and genetic predisposition are critical in confirming a suspected diagnosis and in determining the appropriate intervention for each patient. Specific features influencing management decisions are the presence of rupture, extent of dissection, origin of true or false lumen vessels and signs of organ ischaemia.

NCT ID: NCT05699395 Recruiting - Aortic Dissection Clinical Trials

Quick Recognition of Aortic Dissection

Start date: December 1, 2022
Phase:
Study type: Observational

This is an observational study that establishes a cohort of patients with high risk chest pain who have been identified by CTA for aortic dissection. We then used this cohort to validate the accuracy of identifying aortic dissection based on extremity oximetry and Doppler waveforms.

NCT ID: NCT05659641 Enrolling by invitation - Clinical trials for Cardiovascular Diseases

The Branch-based Intraoperative Stent System in the Treatment of Stanford A Aortic Dissection(BROAD)

BROAD
Start date: January 18, 2023
Phase: N/A
Study type: Interventional

The purpose of the study was to evaluate the safety and efficacy of a branched type intraoperative stent system for the treatment of Stanford type A aortic dissection

NCT ID: NCT05655767 Not yet recruiting - Aortic Aneurysm Clinical Trials

LANDMARC Study: a Study With Focus on Aorta Ascendens

Start date: December 15, 2022
Phase:
Study type: Observational

Rationale: Aortic diameter is currently used as a gold standard in international guidelines for prediction of aorta pathology (aortic aneurysm and aortic dissection). However, aortic diameter has proven to be insufficiently accurate for making decisions about well-timed preventive interventions. The LANDMARC study will take place in line with the FIBAA-bank ('Correlatie tussen cardiovasculaire FIBroseringsgraad en Aorta elongatie, dilatatie en Atria dilatatie (FIBAA-bank): een biobank & databank onderzoek met focus op aorta en atria' (METC-number 2022-3164)), and aims to reveal the undiscovered relationship between WSS (wall shear stress) values and aortic strain. In combination with data from the FIBAA-bank, the LANDMARC study will provide more accurate information for future risk stratification models for cardiovascular pathology (with focus on aortic disease). Objectives: Primary objective: indication of the association between WSS (peak WSS and WSS gradient) (through 4D-flow MR and CT) and aortic strain. Secondary objective: indication of the association between (hemo)dynamic processes within the body (aortic elongation/aortic strain) and (patho-)physiological changes (degree of cardiovascular tissue fibrosis).

NCT ID: NCT05582967 Completed - Aortic Dissection Clinical Trials

The DAShED (Diagnosis of Aortic Syndrome in the ED) Study

DAShED
Start date: September 26, 2022
Phase:
Study type: Observational

Acute aortic syndrome (AAS) is a life-threatening emergency condition affecting the upper aorta affecting ~4000 people in the (United Kingdom; UK) a year with an ED misdiagnosis rate as high as 38%. Previous research has identified several strategies combining clinical probability scoring with blood tests (D-Dimer) to rule out the condition but when applied to a large population (ED) with relatively low numbers of actual cases, these result in a high rate of computed tomographic angiography (CTA) scanning. Current guidelines reflect the uncertainty of existing evidence. This study, the first phase of three, aims to describe the characteristics of ED attendances with possible AAS, to determine the service implications of using different diagnostic strategies and inform future research. The investigators plan to recruit all ED attendances with possible AAS over a 1-4 week period. The investigators plan a prospective and retrospective approach to data collection adopting a waived-consent strategy with endpoint measures describing the characteristics of patients presenting with possible AAS.

NCT ID: NCT05571930 Completed - Aortic Dissection Clinical Trials

Outcomes of Secondary Endovascular Aortic Repair After Initial Frozen Elephant Trunk Procedure

Start date: January 1, 2015
Phase:
Study type: Observational

Objective Complex aortic pathology has been revolutionized with the use of hybrid prostheses such as the Thoraflex® Hybrid Frozen Elephant Trunk (FET). The aim of this study was to evaluate the midterm results of secondary extension of the FET by thoracic endovascular aortic repair (TEVAR). Few data are present in the literature regarding the outcomes of this secondary treatment. The investigators perform a prospective study between 2015 and 2022 in a tertiary aortic center on all consecutive patients having undergone TEVAR after FET implantation. The TEVAR endograft covered most of the 10 cm FET module with 2 to 4 mm oversizing. All patients were monitored by computerized angiography (CTA) at 6-month and yearly thereafter. The aim of this study was the feasibility of theses secondary connexion and the mid term outcomes of the endovascular treatment.

NCT ID: NCT05545566 Completed - Thoracic Ultrasound Clinical Trials

Evaluation of Thoracic Ultrasound in Monitoring Pleural Drainage in Postoperative Thoracic Surgery

EchTHor
Start date: September 5, 2022
Phase: N/A
Study type: Interventional

The investigator would like to conduct a study in patients undergoing thoracic surgery to evaluate the effectiveness of thoracic ultrasound in the decision to discharge the patient after pleural drain removal.

NCT ID: NCT05517356 Recruiting - Aortic Dissection Clinical Trials

Prospective Study of Tailored Management Strategies for Malperfusion Syndrome

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Management strategy of malperfusion syndrome in acute type A aortic dissection (ATAAD) patients remains controversial, with different views on when the surgery should be offered. At present, the mortality of ATAAD patients complicated with malperfusion is stubbornly high. The purpose of this study is to improve the outcomes of ATAAD with malperfusion syndrome. The investigators formulated tailored management strategies for malperfused patients based on the duration of symptoms onset.

NCT ID: NCT05501145 Completed - Pregnancy Related Clinical Trials

Clinical Features, Outcomes, and Therapeutics of Pregnancy-Related Aortic Dissection

Start date: January 1, 2022
Phase:
Study type: Observational

Aortic dissection in pregnancy represents a lethal risk to both the mother and fetus, it has yet to yield the optimal therapeutic strategy. The aim of this study was to characterize the clinical features and outcomes in women with pregnancy-related acute aortic dissection, and to suggest therapeutic guidelines.