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Analgesics, Opioid clinical trials

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NCT ID: NCT06390046 Recruiting - Clinical trials for Anesthesia; Adverse Effect

Opioid-free Anesthesia, Optimization of Anesthesia After Bariatric Surgery

Start date: March 14, 2024
Phase: N/A
Study type: Interventional

Total intravenous general anesthesia and combined general anesthesia are recognized methods used during anesthesia. They allow you to effectively control pain and reduce the number of complications associated with taking large doses of opioid drugs. It should be emphasized that both methods of anesthesia are currently approved for use in routine anesthetic practice, and only the experience, knowledge and preferences of the anesthesiologist determine which technique will be used in a given patient. Both techniques are used in everyday anesthetic practice, but there is no conclusive scientific data confirming the superiority of either method in patients undergoing bariatric surgery, therefore currently only the individual experience, knowledge and preferences of the anesthesiologist determines which technique will be used in a given patient.

NCT ID: NCT06380244 Recruiting - Anesthesia, General Clinical Trials

Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery

Start date: March 10, 2024
Phase: N/A
Study type: Interventional

Due to the increasing number of reports of cancer progression in people undergoing surgery under general anesthesia using opioids, OFA is believed to have a favorable long-term prognostic effect, especially in cancer patients. The opioid-free protocol is also used in postoperative analgesia. It is estimated that up to 75% of surgical patients experience chronic postoperative pain, which has a particularly negative impact on the quality of life. The investigators would like to compare pain during the first 48 postoperative hours of patients undergoing abdominal surgery who would be anesthetized with opioids and without opioids (patients would be randomly assigned to a group) (1, 2, 6, 12, 24 and 48 h after operations). A secondary objective will be to measure total oxycodone consumption in the postoperative period in both groups. Other secondary objectives: assessment of postoperative nausea and vomiting (PONV).

NCT ID: NCT06275191 Enrolling by invitation - Acute Pain Clinical Trials

Alternatives to Dental Opioid Prescribing After Tooth Extraction

ADOPT
Start date: April 16, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test a three-item intervention in oral surgeons who remove teeth. The main questions it aims to answer are: - Can the intervention reduce opioid prescriptions to adolescents and young adults after tooth removal? - Do oral surgeons' beliefs about the intervention and opioid prescribing change? - Do patients that report using opioids after tooth removal have different experiences than patients that do not? Oral surgeon participants will: - Attend a 1-hour education session with a trained pharmacist - Receive patient instructions and blister packs of pain medicine to give to patients - Complete 2 surveys about feasibility and appropriateness Patient participants will complete a survey about pain and medication use after having a tooth removed. Researchers will compare the intervention to usual care to see if it reduces opioid prescribing.

NCT ID: NCT05985629 Recruiting - Pain, Postoperative Clinical Trials

IPACK on Early Pain Scores After ACL Reconstruction

Start date: August 3, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to learn whether using an anesthetic technique called IPACK block will control pain after ACL reconstruction surgery. The main questions it aims to answer are: - if participants who receive the IPACK block prior to ACL reconstruction experience less pain after surgery and at 1 day after surgery - if participants who receive the IPACK block prior to ACL reconstruction require less short-term opioid use immediately after surgery and up to one week after surgery. Participants will be randomized 1:1 to 1 of 2 groups: Use of IPACK block during ACL reconstruction vs. placebo (a placebo is a look-alike substance that contains no active drug). Neither the participant nor the investigator will know which group the participants has been assigned to. Researchers will compare self-reported pain scores and short-term opioid use of all study participants.

NCT ID: NCT05842928 Recruiting - Analgesics, Opioid Clinical Trials

Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy

PARTNER
Start date: March 25, 2023
Phase: N/A
Study type: Interventional

The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER intervention) on reductions in the use of psychotropic, sedative and anticholinergic potentially inappropriate medication (PSA-PIM) compared to a control intervention. The PARTNER intervention comprises (1) education for health care professionals, (2) an interprofessional workshop and case conference, (3) a pharmacy visit with brown bag/medication review and patient empowerment, (4) GP practice visit with shared decision making. The control intervention only comprises a pharmacy visit with brown bag review.

NCT ID: NCT05581901 Completed - Pain, Postoperative Clinical Trials

Perioperative Methadone in Hip Fracture Patients

Start date: January 12, 2023
Phase: Phase 4
Study type: Interventional

Postoperative analgesic treatment needs to be improved. Numerous studies suggest that a single dose of Methadone given during surgery significantly ameliorates postoperative pain and reduces postoperative opioid consumption. Perioperative methadone is already used in isolated cases such as patients with chronic pain or patients with high morphine tolerance. However, it is not routinely used in the elderly and fragile, and there is insufficient reliable evidence on this treatment and population. Further investigation is highly relevant and necessary.

NCT ID: NCT05099055 Completed - Analgesia Clinical Trials

Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study

Start date: March 15, 2022
Phase: Phase 3
Study type: Interventional

The proposed pilot study is a prospective, randomized, controlled, double-blind, single-center pilot study.The aim of this pilot project is to evaluate the feasibility of a phase III study on the use of dexmedetomidine in intrathecal in the context of elective cesarean section. The target population for the study will be adult pregnant women undergoing elective cesarean section under spinal anesthesia. This study will be carried out at a single site, the CHU Sainte-Justine as part of a research internship as part of the anesthesiology residency program at the University of Montreal.

NCT ID: NCT05004519 Completed - Analgesics, Opioid Clinical Trials

Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass

Start date: October 5, 2021
Phase: N/A
Study type: Interventional

Opioid free anesthesia is a recent anesthesia technique with the aim to avoid peroperative use of morphinics to allow a diminution of secondary morphinics effects in the postoperative period. There is no robust data on the real benefits of such procedures. Obese patients are particular at risk of secondary effects of opioids. The aim of our study is to compare opioid free anesthesia to multimodal anesthesia on postoperative morphine consumption after a laparoscopic gastric bypass.

NCT ID: NCT04836169 Not yet recruiting - Pain, Postoperative Clinical Trials

Phase 1: Randomized Evaluation of a System to Deliver Mobile Cognitive Behavioral Therapy

P1RESPECT
Start date: October 2021
Phase: N/A
Study type: Interventional

The clinical study described in this Clinical Investigation Plan (CIP) will be completed in two stages, Phase I and Phase II. The results of Phase I will confirm patient use of InCaveo's EOA system with integrated mobile CBT but without tapering to improve The Pain Catastrophizing Scale (PCS) scores, and secondarily scores on the VNS pain scale, the Tampa Scale of Kinesiophobia (TSK), and patient satisfaction scores in the subacute period (defined as 2 weeks to 3 months post TKR). Statistically significant positive results on the Pain Catastrophizing Scale (PCS) will trigger phase 2. Phase 1 will also inform the detailed conditions and patient management algorithms for Phase II.

NCT ID: NCT04397458 Withdrawn - Analgesics Clinical Trials

Rescue Quadratus Lumborum Blocks for Post-cesarean Pain

Start date: January 1, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess whether quadratus lumborum (QL) block performed 1 day after cesarean delivery will provide supplemental post-cesarean analgesia and reduce opioid requirements.