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Alveolar Bone Loss clinical trials

View clinical trials related to Alveolar Bone Loss.

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NCT ID: NCT05602493 Recruiting - Bone Loss, Alveolar Clinical Trials

A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction

XEOLAS
Start date: November 22, 2022
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the efficacy and safety of the effects of a topical medication on bone remodeling after dental extraction, in order to establish whether such treatment can be a new therapeutic option for said pathology. The participation of 60 patients is expected, who will be divided randomly in equal proportions into two groups. Treatment groups: Group A (30 patients): medication administered topically. Group B (30 patients): placebo with characteristics equal to the drug under investigation.

NCT ID: NCT05533528 Recruiting - Clinical trials for Periodontal Diseases

Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment

Start date: May 3, 2022
Phase: N/A
Study type: Interventional

The objective of this study will be to evaluate a new protocol for the surgical treatment of periodontal disease with two novelties: to make a single incision in the midline of the interproximal area to respect the vascular supply and preserve the granulation tissue with regenerative potential. The investigators will carry out a controlled and randomized clinical trial with a control group (n=25; modified Kirkland flap) and a test group (n=25; experimental surgical protocol: incision in the mid-interproximal area of the papilla and preservation of the granulation tissue). Clinical parameters will be taken at the time of surgery and 12 months follow-up: bleeding on probing (BoP), clinical attachment level (CAL), residual probing depth (rPD),Probing pocket depth reduction (PPDr), recession (REC), interproximal gingival recession (iGR), width of keratinized gingiva (KT), gain of supra-alveolar clinical attachment (SUPRA-AG), early wound healing index (EHI).

NCT ID: NCT05315804 Recruiting - Periodontal Pocket Clinical Trials

Treatment of Intraosseous Periodontal Defects With Amelogenins

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of amelogenins, compared to MINSD alone. A total of 22 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: amelogenin (A) and no-amelogenin group (B).

NCT ID: NCT05311735 Recruiting - Alveolar Bone Loss Clinical Trials

Mineralized and Partial Demineralized Dentin Graft Compared to FDBA

Start date: October 29, 2021
Phase: N/A
Study type: Interventional

The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable results due to its properties of osteogenesis, osteoinduction and osteoconduction. However, bone autografts are rarely used due to the high morbidity associated with harvesting the bone graft from the patient with a second surgical site. Because of the increased risk to the patient with autogenous bone grafts, the current standard of care is an allograft, which is a bone graft harvested from cadaver sources such as Freeze-Dried Bone Allograft (FDBA). While allografts can only possess the qualities of osteoinduction and osteoconduction, they also have dramatically less morbidity due to the lack of a second surgical site. Studies have shown that autogenous dentin grafts promote all three ideal mechanisms for bone regeneration. There are two methods to generate autogenous dentin grafts. One is to collect the extracted tooth and to send it to a tooth bank for the preparation process. The second is to process the extracted tooth in a clinical setting chairside, for a graft. A dentin graft can undergo different treatments such as demineralization, mineralization, and partial-demineralization. Although the autogenous dentin graft has shown positive results for bone regeneration, the comparison between partial-demineralized, mineralized autogenous dentin grafts, and freeze-dried bone grafts in the clinical setting for immediate grafting has not been studied in humans. Thus, there is a need to study the benefits of autogenous dentin partial-demineralized and mineralized grafts versus freeze-dried bone allografts regarding clinical, radiographically (bone volume and density), and efficacy results. This research addresses these areas of need.

NCT ID: NCT05237570 Recruiting - Bone Loss Clinical Trials

Minimally Invasive Sinus Lift Through the Interradicular Septum

Start date: March 2, 2021
Phase: N/A
Study type: Interventional

This study aims to describe a new approach for the reconstruction of the alveolar process in the sinus area. This minimally invasive approach will access the maxillary sinus through the alveolar process, elevating the sinus membrane in the area immediately above it. The regeneration may be achieved in the specific area required for dental implant placement, reducing the morbidity of the procedure.

NCT ID: NCT05073575 Recruiting - Clinical trials for Periodontal Bone Loss

Application of Hyaluronic Acid in the Treatment of Periodontitis

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The aim of the present investigation will be evaluated the healing of suprabony defects following surgical flap elevation and hyaluronic acid application respect to surgical flap elevation alone. A total of 80 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: hyaluronic acid group and no-hyaluronic acid group.

NCT ID: NCT04835532 Recruiting - Bone Loss, Alveolar Clinical Trials

Tenting Screws in Combination With Platelet Concentrate for Vertical Alveolar Ridge Augmentation

Start date: August 10, 2021
Phase: N/A
Study type: Interventional

Alveolar bone resorption often occurs after tooth extraction. At present, guided bone regeneration technique is widely used in clinic since it leads to less trauma and less complications. Tenting screw technology, basic on the classical GBR, implants screws into the surgical area to prevent the barrier membrane from collapsing. Moreover, advanced platelet rich fibrin and injectable platelet-rich fibrin are used to provide the osteogenic function. The investigators intend to increase vertical alveolar bone augmentation by combining tenting screws and A-PRF, I-PRF.

NCT ID: NCT04381585 Recruiting - Periodontitis Clinical Trials

Mini Distractor in Vertically Deficient Bone

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

ADO is a bone regeneration technique, introduced by Chin and Toth in 1996 based in a biological process used for regenerate and consolidate bone between two bone segments obtained after osteotomy.These segments have been gradually separated by the process of distraction. ADO can be performed both horizontally (AHDO) and vertically (AVDO).

NCT ID: NCT04375839 Recruiting - Periodontitis Clinical Trials

Zirconia Vs Titanium Implants in Deficient Ridges

Start date: March 6, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate clinically and radiographically soft tissue around single-implant crowns and peri-implant bone resorption respectively by using zirconia implants or titanium implants in horizontally deficient partially edentulous ridges.

NCT ID: NCT04374383 Recruiting - Periodontitis Clinical Trials

Novel Photosensitizer in The Treatment of Chronic Periodontitis

Start date: June 1, 2019
Phase: Phase 2
Study type: Interventional

The aim of this study is to evaluate the periodontal outcomes after applying antimicrobial photodynamic therapy with a novel photosensitizer as compared to LASER assisted scaling and root planing alone.