Periodontal Bone Loss Clinical Trial
Official title:
Healing of Periodontal Suprabony Defects Following Treatment With Open Flap Debridement With or Without Hyaluronic Acid (HA) Application
The aim of the present investigation will be evaluated the healing of suprabony defects following surgical flap elevation and hyaluronic acid application respect to surgical flap elevation alone. A total of 80 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: hyaluronic acid group and no-hyaluronic acid group.
The objective of the study will be compare the healing of suprabony defects following treatment with either open flap debridement (OFD) and application of hyaluronic acid (HA) with OFD alone. Eighty patients with suprabony periodontal defects will be randomly assigned to treatment with open flap debridement and application of hyaluronic acid (HA Group) or open flap debridement alone (No-HA Group). Primary outcome will be Clinical Attachment Level (CAL) gain, while the secondary outcomes will be Probing Depth (PD) and Gingival Recession (GR). After local anesthesia, an access flap will be prepared. Depending on the mesiodistal width of the interproximal space, two different incision techniques will be selected to access the suprabony defect area. The modified papilla preservation technique (MMPT) will be used at sites with an interproximal width > 2 mm, whereas the simplified papilla preservation technique (SPPT) will be applied at sites with an interproximal width ≤ 2 mm. Then, a mucoperiosteal flap will be reflected. Scaling and root planning will be performed combining the use of metal curettes and power-driven instrumentation by means of ultrasonic scaler. Hyaluronic acid will be applied to exposed roots surface only in HA Group followed, for both groups, by a tension-free primary closure of the interdental papillae and of the mucoperiostal flaps by means of 5-0 monofilament (polypropylene) non-resorbable suturing material. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03997578 -
Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
|
N/A | |
| Completed |
NCT02374216 -
A Prospective Analysis of Failures of Oral Implants
|
N/A | |
| Completed |
NCT02369562 -
A Retrospective Analysis of Failures of Oral Implants
|
||
| Completed |
NCT02218515 -
Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft
|
Phase 4 | |
| Completed |
NCT05631600 -
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
|
Phase 2/Phase 3 | |
| Completed |
NCT03715374 -
Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects
|
N/A | |
| Completed |
NCT04160689 -
Influence of the Implant Connection on Facial Tissues Maturation
|
Phase 4 | |
| Recruiting |
NCT05533528 -
Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment
|
N/A | |
| Completed |
NCT02416700 -
Evaluation of Peri Implant Bone Loss of Immediately Versus Conventionally Loaded Implants With a Single Prosthesis
|
N/A | |
| Completed |
NCT03227367 -
Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.
|
N/A | |
| Not yet recruiting |
NCT04274244 -
Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
|
Phase 4 | |
| Recruiting |
NCT05766878 -
The Rehabilitation of Atrophic Jaws Using Short Implants With Different Surface Characteristics
|
N/A | |
| Recruiting |
NCT03978962 -
Performance and Safety of the Resorbable Collagen Membrane "Ez Cure"
|
||
| Completed |
NCT04043754 -
Platelet-rich Fibrin and Autogenous Bone vs Membrane and Autogenous Bone in Intrabony Defects
|
N/A | |
| Recruiting |
NCT06318247 -
Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets
|
N/A | |
| Active, not recruiting |
NCT00519155 -
Pilot Study on MD05 in Comparison With Open Flap Debridement in Patients Undergoing Periodontal Surgery
|
Phase 2 | |
| Active, not recruiting |
NCT03510780 -
Platelet-rich Fibrin and Autogenous Bone vs Enamel Matrix Derivative and Autogenous Bone in Intrabony Defects
|
N/A | |
| Enrolling by invitation |
NCT05932017 -
Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization
|
||
| Completed |
NCT05360511 -
Erythropoietin Gel as an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects
|
Early Phase 1 | |
| Completed |
NCT04827693 -
The Cortical Shield for Facial Bone Reconstruction
|