Aging Clinical Trial
— MyAgeWellOfficial title:
Successful Ageing: Evidence-based Interventions to Delay Ageing-related Decline
Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no real-world application) and has yet to show robust evidence that such interventions are stable and suitable in the long-term. The investigators aim to examine whether these interventions can, over four years, significantly slow down the normal rate of ageing-related decline.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | May 2030 |
Est. primary completion date | May 2029 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years and older |
Eligibility | Malaysian older adults aged 60 and above who fulfil the following criteria will be recruited: Inclusion Criteria: - Healthy and this includes those seeking regular medical attention, - Have some form of mobility (ability to walk short distances at least 3m), - Able to communicate in at least one of the following languages: English, Malay, Mandarin, Tamil. Exclusion Criteria: - Older adults with a history of stroke, - Diagnosis of neurodegenerative diseases (such as Alzheimer's disease or Parkinson's) or psychiatric disorders, - Uncorrected auditory and/or visual impairments, - Currently on psychiatric medications, - Immobile, - Require full-time caregiver assistance, - With comprehension impediments from the assessment portion of this project, - A Montreal Cognitive Assessment (MoCA) score of <13. |
Country | Name | City | State |
---|---|---|---|
Malaysia | Sunway University | Petaling Jaya | Selangor |
Lead Sponsor | Collaborator |
---|---|
Sunway University |
Malaysia,
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Erickson KI, Leckie RL, Weinstein AM. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014 Sep;35 Suppl 2:S20-8. doi: 10.1016/j.neurobiolaging.2014.03.034. Epub 2014 May 14. — View Citation
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Yong MH, Lawrie L, Schaefer A, Phillips LH. The Effects of Adult Aging and Culture on Theory of Mind. J Gerontol B Psychol Sci Soc Sci. 2022 Feb 3;77(2):332-340. doi: 10.1093/geronb/gbab093. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in cognitive scores | Changes in cognitive scores will be evaluated using Montreal Cognitive Assessment (MoCA). Possible scores range from 0-30. Higher scores indicate less cognitive impairment. | 4 years | |
Primary | Changes in electroencephalogram (EEG) | Onset of neural responses to errors in the Go/No Go task will be evaluated using EEG. | 4 years | |
Primary | Changes in structural magnetic resonance imaging (MRI) | Relationship between Wisconsin Card Sorting Test performance and grey matter volume will be evaluated using structural MRI. | 4 years | |
Primary | Cost-benefit analysis of intervention | The economic benefits from the interventions will be evaluated and will cover three aspects: financial, productivity and health. | 4 years | |
Primary | Changes in levels of human salivary lactoferrin | Changes in levels of human salivary lactoferrin (ng/mL) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. Low levels of lactoferrin can potentially indicate higher risk for cognitive impairment. | 4 years | |
Primary | Changes in levels of human salivary C-reactive proteins | Changes in levels of human salivary C-reactive proteins (CRP, mg/L) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. High levels of CRP can indicate inflammation and its association with greater cognitive decline. | 4 years | |
Primary | Changes in salivary telomere length | Changes in salivary telomere length (T/S ratio) will be measured using quantitative PCR. A higher T/S ratio indicates better preservation of telomere length hence better preservation of cognition. | 4 years | |
Secondary | Changes in depression scores | Changes in depression scores will be measured using part of the Center for Epidemiologic Studies Depression Scale (CES-D). Possible scores range from 0-42. Higher scores indicating greater frequency of depressive experiences. | 4 years | |
Secondary | Changes in anxiety scores | Changes in anxiety scores will be measured using part of the Form Y of the State-Trait Anxiety Inventory (STAI). Possible scores range from 6-24. Higher scores indicate greater anxiety. | 4 years |
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