Aging Clinical Trial
Official title:
Healthy Longevity and Mortality in Long-living Adults: Contributors and Causes - Lifestyle, Socioeconomic Background, and Replicative Aging
NCT number | NCT06268132 |
Other study ID # | MLS90 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | December 25, 2019 |
Est. completion date | December 31, 2025 |
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia. The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity. The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.
Status | Recruiting |
Enrollment | 4000 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 90 Years and older |
Eligibility | Inclusion Criteria: - Informed consent - 90 years of age or above Exclusion Criteria: - Refusal to participate or to provide informed consent; - Any other criteria deemed reasons for exclusion by the Principal Investigator. |
Country | Name | City | State |
---|---|---|---|
Russian Federation | RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation | Moscow |
Lead Sponsor | Collaborator |
---|---|
Center for Strategic Planning, of the Federal Medical and Biological Agency | Pirogov Russian National Research Medical University |
Russian Federation,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mortality among long-living adults | Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed. | at least 1 year after inclusion in the study | |
Primary | Morbidity among long-living adults | Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed. | at least 1 year after inclusion in the study | |
Secondary | Aging phenotypes | Identification of successful and unsuccessful aging phenotypes | at least 2 years after inclusion in the study | |
Secondary | Social, economic, and medical- history-related determinants | Identification of social, economic, and medical- history-related determinants of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study | |
Secondary | Genetic determinants | Identification of the genetic determinants of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study | |
Secondary | Epigenetic determinants | Identification of the epigenetic determinants (methylation sites) of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study | |
Secondary | Metagenomic determinants | Identification of the metagenomic determinants (16S-rSeq) of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Recruiting |
NCT06032065 -
Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD (SMART PAD)
|
Phase 3 | |
Completed |
NCT05293730 -
Trial of the Impact of the Electronic Frailty Integrated With Social Needs
|
N/A | |
Recruiting |
NCT03932162 -
Gene Expression Changes In Young and Geriatric Skin
|
Early Phase 1 | |
Completed |
NCT04064528 -
Effects of Age on Amino Acid Delivery to Tendon
|
N/A | |
Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
Completed |
NCT06029920 -
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
|
N/A | |
Recruiting |
NCT05566938 -
Study to Design a Precision Nutrition Strategy at a Group Level in the Elderly
|
N/A | |
Recruiting |
NCT05543980 -
Leg Heat Therapy in Elderly Individuals
|
Phase 2 | |
Completed |
NCT04894929 -
Comprehensive Geriatric Assessment in the Monitoring of Functional Improvement
|
N/A | |
Not yet recruiting |
NCT06071130 -
Emotion, Aging, and Decision Making
|
N/A | |
Enrolling by invitation |
NCT04641663 -
Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)
|
N/A | |
Completed |
NCT04088006 -
The Evaluation of Efficacy and Safety of Hyaluronic Acid Injection on Skin Moisturization and Elasticity
|
N/A | |
Completed |
NCT03695081 -
Patient Pathway Pharmacist - Optimal Drug-related Care
|
N/A | |
Recruiting |
NCT05424263 -
Acetate and Age-associated Arterial Dysfunction
|
Phase 2 | |
Completed |
NCT05601713 -
Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling
|
N/A | |
Completed |
NCT04551339 -
Zinc Versus Multivitamin Micronutrient Supplementation in the Setting of COVID-19
|
N/A | |
Recruiting |
NCT04997577 -
Speech Perception and High Cognitive Demand
|
N/A | |
Completed |
NCT05922475 -
Efficacy of Pre-sleep or Post-exercise Protein During 12 Weeks of Resistance Exercise Training
|
N/A | |
Completed |
NCT04015479 -
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
|
N/A |