Aging Clinical Trial
Official title:
Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults
The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.
| Status | Not yet recruiting |
| Enrollment | 300 |
| Est. completion date | December 30, 2026 |
| Est. primary completion date | March 30, 2026 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Must be a local adult resident of Macau - Age above 50 years for older adult cohort - Younger adults individuals above 18 will be included as control comparators Exclusion Criteria: - History of neurological injury or disease - Current use of medications that affect brain function or blood flow - Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker) - Claustrophobia - Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm) - Inability to provide informed consent - Pregnancy - Being under the legal age of adulthood (children) - Incarcerated individuals (prisoners) |
| Country | Name | City | State |
|---|---|---|---|
| Macau | Centre for Cognitive and Brain Sciences of the University of Macau | Macao | Macao SAR |
| Lead Sponsor | Collaborator |
|---|---|
| University of Macau |
Macau,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version | The MoCA will be administered to derive a normative data set representative of the older adult population in Macau. | From February 2024 to January 2026 | |
| Primary | Normative Data for the Mini-Mental State Examination (MMSE) | The MMSE will be administered to derive a normative data set representative of the older adult population in Macau. | From February 2024 to January 2026 | |
| Primary | Normative Scores for Computerized Neuropsychological Tasks | Neuropsychological tasks will be employed to measure selective attention capacity and processing speed in the study cohort. These tasks will provide quantifiable data on the efficiency and accuracy of cognitive processing. The collective performance on these tasks will be used to establish benchmark values - including means, medians, and ranges - that define the normative standards for these cognitive abilities in the population. | From February 2024 to January 2026 | |
| Secondary | Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI) | fMRI data will be collected to identify patterns of neural activation associated with cognitive task performance. | From February 2024 to January 2026 | |
| Secondary | Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS) | fNIRS will be employed to measure cerebral blood flow and oxygenation during cognitive tasks. | From February 2024 to January 2026 | |
| Secondary | Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG) | EEG will be utilized to record the electrical activity of the brain during cognitive tasks. Key outcome metrics will include event-related potentials (ERPs) amplitudes and latencies, with mean values and variability measures reported for the cohort. | From February 2024 to January 2026 |
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