Hydrogen-Rich Water and Exercise-Related Biomarkers in Men and Women Over 50 Years

Aging Clinical Trial

— HYDRORES  

Official title:

The Effects of Drinking Hydrogen-rich Water for 6 Weeks on Exercise-related Biomarkers in Men and Women Over 50 Years Following Resistance Training Program: a Randomized Controlled Pilot Trial

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06163287
• Other study ID #: HRW-1-23-AL
• Status: Active, not recruiting
• Phase: N/A
• Start date: October 1, 2023
• Est. completion date: March 31, 2024

Study information

• Verified date: December 2023
• Source: University of Novi Sad, Faculty of Sport and Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study investigates the impact of consuming hydrogen-rich water over a six-week period on exercise-related biomarkers among individuals aged over 50, both men and women, who undergo a resistance training program. This research aims to discern the potential benefits of hydrogen-infused water consumption concerning exercise-related markers in an aging demographic post-resistance training.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 28
• Est. completion date: March 31, 2024
• Est. primary completion date: March 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 65 Years

Eligibility

Inclusion Criteria:

• Age 50 - 65 years (at least 50% would be over 60 years)
• Body mass index 18.5 - 29.9 kg/m2
• Free of major chronic diseases or acute disorders
• Resistance exercise naïve (no resistance traiing during 6 months before study commences)

Exclusion Criteria:

• History of dietary supplement use during the 4 weeks before study commences
• Unwillingness to return for follow-up analysis

Related Conditions & MeSH terms

• Aging

Intervention

Dietary Supplement:
• Supplement
Dietary supplement containing molecular hydrogen
• Placebo
Inert substance

Locations

Country	Name	City	State
Serbia	FSPE Applied Bioenergetics Lab	Novi Sad	Vojvodina

Sponsors (1)

Lead Sponsor	Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (3)

Korovljev D, Stajer V, Javorac D, Ostojic SM. Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. Eur Geriatr Med. 2018 Oct;9(5):729-730. doi: 10.1007/s41999-018-0087-6. Epub 2018 Jul 31. No abstract available. — View Citation

Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci. 2018 Feb;187(1):85-89. doi: 10.1007/s11845-017-1638-4. Epub 2017 May 30. — View Citation

Zanini D, Todorovic N, Korovljev D, Stajer V, Ostojic J, Purac J, Kojic D, Vukasinovic E, Djordjievski S, Sopic M, Guzonjic A, Ninic A, Erceg S, Ostojic SM. The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Exp Gerontol. 2021 Nov;155:111574. doi: 10.1016/j.exger.2021.111574. Epub 2021 Oct 1. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	36-Item Short Form Health Survey	Short Form Health Survey total score, minimum and maximum possible score of between 0 and 100, with higher scores mean better outcome	Change from baseline 36-Item Short Form Health Survey total score at 6 weeks
Secondary	Grip strength	Muscular strength generated by one's forearm muscles	Change from baseline grip strength at 6 weeks
Secondary	Myoglobin	Level of myoglobin in serum	Change from baseline serum myoglobine at 6 weeks
Secondary	Pittsburgh Sleep Quality Index	Pittsburgh Sleep Quality Index score, a score ranging from 0 to 3, with 3 indicating the greatest dysfunction	Change from baseline Pittsburgh Sleep Quality Index score at 6 weeks
Secondary	Dehydroepiandrosterone	Level of dehydroepiandrosterone in serum	Change from baseline serum dehydroepiandrosterone at 6 weeks