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The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Aging Clinical Trial

Official title:
The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Clinical Trial Summary

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

Clinical Trial Description

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar in young and elderly adults. This study involves direct vaccination of human volunteers. The endpoints will be determining how vaccination affects neutrophil responses and linking those neutrophil responses to antibody responses following vaccination. The main results will be: 1. Elucidating how neutrophils kill bacteria before and after vaccination 2. Elucidate the phenotype of neutrophils before and after vaccination 3. Elucidate how neutrophils interact with B and T cell in vitro before and after vaccination 4. Measure antibody levels and function before and after vaccination 5. Correlate neutrophil responses to antibody levels and function ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06128915
Study type Interventional
Source State University of New York at Buffalo
Contact Elsa Bou Ghanem, PhD
Phone 7168292422
Email elsaboug@buffalo.edu
Status Recruiting
Phase Phase 4
Start date January 8, 2024
Completion date May 31, 2026
View Details
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