Agility Training for Older Adults to Improve Fall Risk Factors

Aging Clinical Trial

— AgilE  

Official title:

Agility Training for Older Adults: A Randomized Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05727254
• Other study ID #: 2222-00145
• Status: Recruiting
• Phase: N/A
• Start date: July 13, 2022
• Est. completion date: December 2023

Study information

• Verified date: February 2023
• Source: University of Basel
• Contact: Eric Lichtenstein, MSc
• Phone: +41796415225
• Email: e.lichtenstein[@]unibas.ch
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. 40 subjects are recruited that are generally health and between 60 and 80 years of age. The interventions is based around exercises, where different tasks have to be solved simultaneously rather than serially, as has previously been done.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: December 2023
• Est. primary completion date: December 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• willing to be randomized to either arm
• ability to travel to the sports facility twice a week
• understanding the german language

Exclusion Criteria:

• smoking, obesity
• history of cardiovascular, pulmonary or chronic inflammatory disease
• vision impairments
• orthopaedic problems preventing them from participating in an exercise program
• history of osteoporosis or recent low trauma fracture
• less than two weeks during the intervention period
• not have taken part in a structured exercise program more than once a week in the past three months

Related Conditions & MeSH terms

• Aging
• Cognitive Decline
• Cognitive Dysfunction
• Sarcopenia

Intervention

Behavioral:
• Agility training
Multi-component (strength, balance, cognition) exercise training.
• Exercise recommendations
Participants are being given the standard recommendations how much exercise and what type older adults should do.
• Exercise diary
Participants are instructed to write down their physical activity and exercises.

Locations

Country	Name	City	State
Switzerland	Departement für Sport, Bewegung und Gesundheit	Basel	Basel-Stadt

Sponsors (1)

Lead Sponsor	Collaborator
Oliver Faude

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Corticospinal Inhibition	Difference between paired and single pulse motor evoked potential by transcranial magnetic stimulation.	16 weeks
Other	Voluntary activation	Degree of ability to contract the soleus muscle voluntarily.	16 weeks
Primary	Isometric knee-extension strength	Strength in torque (N*m) of the quadriceps femoris muscle. Measured on an isokinetic device in an isometric condition.	16 weeks
Secondary	Isometric knee-flexion strength	Strength in torque (N*m) of the hamstring muscle group measured on an isokinetic device in an isometric condition.	16 weeks
Secondary	Cognitive Processing Speed	Eriksen flanker task performance measured be reaction speed in milliseconds and accuracy in percentage.	16 weeks
Secondary	Cognitive Impulsiveness	Go / No-Go task performance measured by reaction speed in milliseconds and accuracy in percentage.	16 weeks
Secondary	Balance Performance	Staying as stable as possible during ten seconds in tandem stance eyes open condition. Center of pressure sway path length in mm and average sway speed in m/s is calculated.	16 weeks
Secondary	Hand Grip Strength	Using a handheld dynamometer with an extended arm squeezing as hard as possible. Measured in N.	16 weeks
Secondary	Counter movement jump power	Measured on a force plate participants are instructed to jump as high as possible with their hands akimbo. Peak of the time-power curve in Watts.	16 weeks
Secondary	Blood Pressure	Blood pressure cuff on the right arm at the height of the aorta. Measured in mmHG.	16 weeks
Secondary	Pulse Wave Velocity	Estimated from a mobile blood pressure cuff (mobil-O-graph) on the right arm. Measured in m/s.	16 weeks
Secondary	Retinal vessel diameter	A photo is made from the retinal vessels with a static vessel analyzer (camera)through the eye and the vessel diameters are measured in mikrometers.	16 weeks
Secondary	Quality of Life Questionnaire	26 item questionnaire (WHOQOL-Bref). Every answer is rated on a scale from 1 to 5. Aggregate Score from 0 to 100.	16 weeks
Secondary	Fall Efficacy	16 item qestionnaire (Fall Efficacy Scale). Every answer is rated on a scale from 1 to 4.	16 weeks
Secondary	Sleep Disturbances	7 item questionnaire (Insomnia Severity Index). Every answer is rated on a scale from 1 to 5.	16 weeks
Secondary	Stress	10 item qestionnaire (Perceived Stress Scale). Every answer is rated on a scale from 1 to 5.	16 weeks
Secondary	Depression	15 item questionnaire (Center for Epidemiological Studies Depression Scale). Every answer is rated on a scale from 1 to 4.	16 weeks