Study to Design a Precision Nutrition Strategy at a Group Level in the Elderly

Aging Clinical Trial

— NUTRIMET  

Official title:

Study to Design a Tailored Precision Nutrition Strategy Based on Metabotypes in the Elderly

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05566938
• Other study ID #: NUTRIMET
• Status: Recruiting
• Phase: N/A
• Start date: September 5, 2022
• Est. completion date: September 2023

Study information

• Verified date: March 2023
• Source: Fundació Eurecat
• Contact: Alba Raventós
• Phone: 937417700
• Email: araventos[@]csdm.cat
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

From a public health point of view, personalized nutritional recommendations, at the individual level, are difficult to achieve in the short-medium term, especially in population segments with less purchasing power. Therefore, a more realistic vision in the short term and with a more favourable cost/effectiveness ratio consists of carrying out dietary advice at the group level through the identification of metabotypes, which can be defined as groups of individuals with similar metabolic profiles. The application of tailored precision nutrition aimed at the elderly is detected as a strategy to understand the different alterations associated to aging and to design innovative nutritional interventions that address this physiological process, favouring a healthy ageing.

Description:

The main objective of this study is to design a precision nutrition strategy at the group level in older people, based on the identification of metabotypes and enterotypes, and combining complementary variables such as anthropometric, biochemical and clinical biomarkers. The specific objectives of the study are: 1. To identify metabotypes (clusters) in a cohort of older people, through an integrated approach of metabolomics, intestinal microbiota and anthropometric, biochemical and clinical biomarkers. 2. To develop digital tools, integrated into a mobile application, that allow the precise assignment of automated nutritional recommendations at the group level based on the metabotypes obtained, as well as promoting the adoption of new dietary habits through diet self-monitoring. 3. To evaluate the concordance of the nutritional recommendations generated at the group level by means of an automated system with the recommendations elaborated at the individual level by a nutritionist. A total of 150 elderly people (age> 65 years) will be recruited. In order to identify the metabotypes, blood, urine and feces will be collected to determine biomarkers of inflammation, glucose metabolism, lipid metabolism, oxidative stress, bone health, sarcopenia, clinical biomarkers, intestinal microbiota and metabolomics. In addition, the following measures will be analyzed: food intake (3-day dietary records), anthropometric variables, blood pressure, bowel movement and stool consistency, diagnosis of dysphagia and sarcopenia, and measurement of frailty, muscle strength and physical performance. By using clustering tools, groups with similar metabolism and microbiota profiles (metabotypes and enterotypes) will be defined and the variables that contribute most significantly to the differentiation between clusters will be determined. The nutritionist team will elaborate tailored dietary advice for each cluster. In parallel, mobile health tools will be developed in order to allow the volunteers to recieve and check these nutritional recommendations, and to facilitate behaviour change through dietary self-monitoring. The volunteers will also recieve personalized nutritional recommendations individually. The tailored nutritional recommendations given at the group level (metabotypes) will be compared with the individually personalized recommendations. The objective is to obtain a high coincidence (> 80%) in the dietary recommendations between these two approaches. The total duration of the study for each volunteer will be 14 months. During this period, participants will make 4 visits: - A pre-selection visit (to check inclusion/exclusion criteria) (V0; day 1) and, if the inclusion criteria are met, - A study visit (V1; day 5) in which samples will be collected from faeces, urine and blood; and the following will be measured: food intake (3-day dietary record), anthropometry, body composition, blood pressure, frailty, muscle strength, physical performance, bowel movement and stool consistency, diagnosis of dysphagia and sarcopenia. - A study visit (V2; day 30) in which individualized nutritional recommendations will be provided to the volunteer by the nutritionist. - A telephonic study visit (V3; month 14) in which an explanation of the instructions to download and run the App through the volunteer will have access to targeted dietary recommendations (according to the assigned cluster) will be given.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 150
• Est. completion date: September 2023
• Est. primary completion date: September 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 66 Years and older

Eligibility

Inclusion Criteria:

1. Men and women over 65 years of age

2. Have or have access (caregiver, family member) to a smartphone or tablet with Android operating system version 6 (API 23) or higher, with internet access

3. Have the signed informed consent before the initial screening visit

Exclusion Criteria:

1. Have food allergies or intolerances

2. Have diarrhea

3. People with irritable bowel syndrome or inflammatory bowel disease.

4. Present some severe chronic pathology with clinical manifestations such as cardiovascular disease, coronary disease, chronic kidney disease or cancer.

5. Participate or have participated in another clinical study or nutritional intervention in the 30 days prior to inclusion in the study.

6. Following a prescribed diet for any reason, including weight loss, in the past month.

7. Recent use of antibiotics in the last two weeks.

8. Consumption of prebiotics and/or probiotics in the 30 days prior to the study

9. Have a BMI <18.5 kg/m2

10. Smoke more than 10 cigarettes a day

11. Consume more than 14 standard drinking units (SDUs) of alcoholic beverages per week

Related Conditions & MeSH terms

• Aging

Intervention

Other:
• Tailored nutritional recommendations for each metabotype
Tailored nutritional recommendations for each metabotype detected (at the group level), that will be delivered through a mobile application. Moreover, each volunteer will recieve individualized nutritional recommendations.

Locations

Country	Name	City	State
Spain	Consorci Sanitari del Maresme	Mataró

Sponsors (5)

Lead Sponsor	Collaborator
Fundació Eurecat	Bana Hosting, Centro de investigación biomédica en red enfermedades hepáticas y digestivas (Ciberhd), Consorci Sanitari del Maresme (CsdM), Sixtemia

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concordance between the nutritional recommendations generated at the group level and at the individual level	To assess the concordance between the two methods used (group vs individual nutritional recommendations) the following will be considered: How many of the nutrients identified as main objectives match between the 2 methods (in percentage); How many nutritional recommendations generated by the 2 methods agree with each other (in percentage)	At the final point (month 14)