Aging Clinical Trial - Modulating Neurocognitive Processes of Learning to

Status Not yet recruiting

Clinical Trial Summary

Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. Optimal trust-related decision making and avoiding exploitation require the ability to learn about the trustworthiness of social partners across multiple interactions, but the role that learning plays in determining age deficits in trust decisions is currently unknown. The proposed work is conceptually embedded in the Changes in Integration for Social Decisions in Aging (CISDA) framework. This framework describes how the integration of decision-relevant information is impacted by trajectories of change in theory of mind, memory systems, and social-emotional processing with age. Two innovative trust-learning paradigms - the Social Iowa Gambling Task (sIGT) and the FLorida-Arizona Gambling Task (FLAG) - will be leveraged to test CISDA predictions. Aim: Probe the malleability of the underlying neurocircuitry of trust-learning deficits in aging. This study will utilize real-time fMRI neurofeedback to train older adults in brain activity up-regulation toward enhanced trust-related learning in aging and confirm critical mechanisms of experience-dependent social decisions in aging. Grant R01AG072658 Aim 3: Test the malleability of trust-learning neurocircuitry toward optimized trust-related decision making in aging.

Clinical Trial Description

This study will apply rtfMRI neuro-feedback training as an intervention method, to demonstrate that older adults can be trained in volitional brain activity up-regulation, reducing their trust-learning deficits. The study will compromise of several MRI sessions including pre-training, training, and post-training scans. After post-training, the effects of neuro-feedback training on far transfer to phishing susceptibility and exploitation risks will be assessed using PEST and survey measures. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05457725
Study type	Interventional
Source	University of Florida
Contact	Dana Arnold
Phone	401-617-6061
Email	arnold.d@ufl.edu
Status	Not yet recruiting
Phase	Early Phase 1
Start date	July 1, 2024
Completion date	March 31, 2027

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms