Aging Clinical Trial
— We-LongevityOfficial title:
Westlake Longevity Cohort
The Westlake Longevity Cohort (We-Longevity) is a prospective cohort study among centenarians, nonagenarians, senior citizens and their family members up to three generations living in Lishui, China. The primary aim of this cohort is to characterize the multi-omics molecular characteristics of healthy longevity and their dynamic trajectories. Another aim of We-Longevity is to investigate the association of dietary and lifestyle with the multi-omics molecular characteristics of healthy longevity, and to facilitate the development of personalized nutritional/lifestyle recommendation for the public.
Status | Recruiting |
Enrollment | 1200 |
Est. completion date | November 14, 2031 |
Est. primary completion date | November 14, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: - Participants aged 50 years or order. - Participants live in Lishui, China. - Participants intend to remain in Lishui for =3 years. Exclusion Criteria: - Participants with cancer, serious medical disorders or infectious diseases. |
Country | Name | City | State |
---|---|---|---|
China | Lishui City People's Hospital | Lishui | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Westlake University | The Sixth Affiliated Hospital of Wenzhou Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | aging | Physical frailty will be evaluated by using Fried's criteria. | 36 months | |
Primary | Gut microbiota | Fecal microbiome will be analyzed by 16S rRNA gene sequencing and metagenome sequencing. | 36 months | |
Primary | Metabolomics of serum and gut microbiome | Metabolomics of serum and gut microbiome will be analyzed by liquid chromatograph-mass spectrometer (LC/MS). | 36 months | |
Primary | Proteomic profiling of serum | Proteomic characterization of serum will be analyzed by liquid chromatograph-mass spectrometer (LC/MS). | 36 months | |
Primary | Genome | Genomic characterization will be analyzed by Illumina ASA-750K arrays. | 36 months | |
Secondary | Cognitive function | Cognitive function will be evaluated by using Mini-Mental State Examination (MMSE). | 36 months | |
Secondary | Blood glucose examination of blood samples | Blood glucose will be analyzed by automatic biochemical analyser. | 36 months | |
Secondary | Blood blood lipids examination of blood samples | Blood blood lipids (HDL, LDL, TC and TG) will be analyzed by automatic biochemical analyser. | 36 months | |
Secondary | Serum cytokines examination of blood samples | Serum cytokines (IFN?, IL10, IL12p70, IL13, IL1ß, IL2, IL4, IL6, IL8 and TNFa) will be analyzed by electrochemiluminescence immunoassay. | 36 months | |
Secondary | Serum neurotranszmitters examination of blood samples | Serum neurotranszmitters (dopamine, choline, acetyl choline, tyramine, tryptamine, 5-hydroxyindoleacetic acid, phenylpyruvic acid, 3,4-dihydroxyphenylacetic acid and 3-hydroxyo-aminobenzoic acid) will be analyzed by liquid chromatograph-mass spectrometer (LC/MS). | 36 months |
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