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Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

Aging Clinical Trial

Official title:
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP): a Prospective Observational Study

Clinical Trial Summary

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05246813
Study type Observational
Source Imelda Hospital, Bonheiden
Contact Michaël R. Laurent, MD PhD
Phone +32485143267
Email michael.laurent@imelda.be
Status Recruiting
Phase
Start date February 11, 2022
Completion date December 31, 2025
View Details
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