Aging Clinical Trial
— HYPOXAGEOfficial title:
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.
Status | Recruiting |
Enrollment | 64 |
Est. completion date | September 2024 |
Est. primary completion date | March 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years to 80 Years |
Eligibility | Inclusion Criteria: - 60 to 80 years of age; - Being physically inactive (less than 150 min/week of moderate to intense physical activity); - No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program; - Health coverage; - Being able to provide written fully informed consent. Exclusion Criteria: - Body-mass index >30 kg/m2; - Smoking (> cigarettes/day); - Alcohol use (> 10g/day); - Mental disorder or history of mental disorder; - Beta-blockade treatment; - Inability or refusal to provide informed consent; - No health coverage - People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials; - People deprived of freedom by judicial or administrative decision; - People subject to legal protection, who cannot be included in clinical trials. |
Country | Name | City | State |
---|---|---|---|
France | CHU Grenoble Alpes | La Tronche | Auvergne Rhône-Alpes |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Middle cerebral artery flow velocity | Changes in middle cerebral artery flow velocity in response to hypercapnia (5% CO2) | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Peak oxygen uptake | Peak oxygen uptake during a cardiopulmonary exercise test | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Flow-mediated dilation | Flow-mediated dilation in response to ischemia-reperfusion of the brachial artery | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Blood pressure | 24h (systolic, diastolic and mean) blood pressure assessment | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Sleep | Sleep features assessed by polygraphy | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Cognitive function | Cognitive function assessed by the Montreal Cognitive Assessment questionnaire | Before intervention; right after intervention; 2 months after intervention | |
Secondary | Health-related quality of life | Health-related quality of life assessed by the SF-36 questionnaire | Before intervention; right after intervention; 2 months after intervention |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Recruiting |
NCT06032065 -
Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD (SMART PAD)
|
Phase 3 | |
Completed |
NCT05293730 -
Trial of the Impact of the Electronic Frailty Integrated With Social Needs
|
N/A | |
Recruiting |
NCT03932162 -
Gene Expression Changes In Young and Geriatric Skin
|
Early Phase 1 | |
Completed |
NCT04064528 -
Effects of Age on Amino Acid Delivery to Tendon
|
N/A | |
Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
Completed |
NCT06029920 -
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
|
N/A | |
Recruiting |
NCT05543980 -
Leg Heat Therapy in Elderly Individuals
|
Phase 2 | |
Recruiting |
NCT05566938 -
Study to Design a Precision Nutrition Strategy at a Group Level in the Elderly
|
N/A | |
Completed |
NCT04894929 -
Comprehensive Geriatric Assessment in the Monitoring of Functional Improvement
|
N/A | |
Not yet recruiting |
NCT06071130 -
Emotion, Aging, and Decision Making
|
N/A | |
Enrolling by invitation |
NCT04641663 -
Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)
|
N/A | |
Completed |
NCT04088006 -
The Evaluation of Efficacy and Safety of Hyaluronic Acid Injection on Skin Moisturization and Elasticity
|
N/A | |
Completed |
NCT03695081 -
Patient Pathway Pharmacist - Optimal Drug-related Care
|
N/A | |
Recruiting |
NCT05424263 -
Acetate and Age-associated Arterial Dysfunction
|
Phase 2 | |
Completed |
NCT05601713 -
Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling
|
N/A | |
Completed |
NCT04551339 -
Zinc Versus Multivitamin Micronutrient Supplementation in the Setting of COVID-19
|
N/A | |
Recruiting |
NCT04997577 -
Speech Perception and High Cognitive Demand
|
N/A | |
Completed |
NCT05922475 -
Efficacy of Pre-sleep or Post-exercise Protein During 12 Weeks of Resistance Exercise Training
|
N/A | |
Completed |
NCT04015479 -
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
|
N/A |