Aging Clinical Trial
— PIEOfficial title:
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.
Verified date | May 2024 |
Source | University of Exeter |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In healthy middle-aged men and women, what is the effect of dietary energy restriction and energy surplus on daily muscle protein synthesis rates and muscle morphology, compared to energy balance, during free-living and immobilisation?
Status | Active, not recruiting |
Enrollment | 36 |
Est. completion date | June 2025 |
Est. primary completion date | June 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 35 Years to 65 Years |
Eligibility | Inclusion Criteria: Age 35-65 Healthy Non-smoker Recreationally active Exclusion Criteria: Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes) Any diagnosed cardiovascular disease or hypertension Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of =150mmHg over two or more measurements and an average diastolic blood pressure of =90mmHg over two or more measurements.) Chronic use of diabetic medication. A personal or family history of epilepsy, seizures or schizophrenia. Allergic to mycoprotein / Quorn, penicillin, or cow's milk. Any musculoskeletal injury that may impair their use of crutches. Any diagnosed severe digestive illness. Any diagnosed severe autoimmune disease. Any diagnosed cancer. Any metal fragments in the eyes, a pacemaker, or metal implants in the body that preclude MRI scanning. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Sport & Health Sciences University of Exeter | Exeter | Devon |
United Kingdom | University of Exeter, Sports & Health Sciences, College of Life & Environmental Sciences | Exeter | Devon |
Lead Sponsor | Collaborator |
---|---|
University of Exeter |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle protein synthesis (MPS) | Daily muscle protein synthesis rates, expressed as fractional synthetic rate (FSR) (%/day) | 6 days (3 days free-living, 3 days immobilised) | |
Secondary | Muscle morphology. | Changes in muscle size, measured via MRI scanning, during immobilisation. | 3 day immobilisation phase. |
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