Aging Clinical Trial - Bloodflow Restricted Exercise in Healthy Ageing

Status Enrolling by invitation

Clinical Trial Summary

The overall objective of this study is to investigate the efficacy of low-intensity blood flow restricted resistance exercise (BFRRE) to promote health beneficial skeletal muscle adaptations and augment muscle function in a healthy older population. This objective will be achieved by in-dept evaluation of skeletal muscle cellular and functional characteristics prior to and after an intervention period comprising 6 weeks of BFRRE or non-exercise control intervention in healthy older subjects. A special focus is placed on the ability of BFRRE to stimulate skeletal muscle protein synthesis and augment muscle stem cell function. Furthermore, recent findings suggests that similar exercise interventions in a population of patients with heart failure (HF) does not stimulate the desired adaptations. In accordance, we aim to compare the adaptive response to BFRRE amongst HF patients and the enrolled age-matched healthy individuals from the present investigation. The findings of the current study will expand our understanding of how low-intensity resistance exercise alternatives might be viable in promoting muscle anabolism to combat the loss of muscle mass observed with ageing as well as the potential anabolic resistance accompanying HF diagnosis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Aging

Clinical Trial Details

NCT number	NCT04712955
Study type	Interventional
Source	University of Aarhus
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	January 19, 2021
Completion date	July 1, 2025

View Details

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