Aging Clinical Trial
— H2AGEOfficial title:
The Effects of Six-month Hydrogen-rich Water Intake on Molecular and Phenotypic Biomarkers of Aging in Men and Women Aged 70 Years and Over: a Randomized-controlled Trial
Verified date | April 2021 |
Source | University of Novi Sad, Faculty of Sport and Physical Education |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.
Status | Completed |
Enrollment | 44 |
Est. completion date | April 1, 2021 |
Est. primary completion date | March 15, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 70 Years and older |
Eligibility | Inclusion Criteria: - Age > 70 years - Free of acute disorders Exclusion Criteria: - History of dietary supplement use during the past 4 weeks |
Country | Name | City | State |
---|---|---|---|
Serbia | FSPE Applied Bioenergetics Lab | Novi Sad | Vojvodina |
Lead Sponsor | Collaborator |
---|---|
University of Novi Sad, Faculty of Sport and Physical Education |
Serbia,
Xia X, Chen W, McDermott J, Han JJ. Molecular and phenotypic biomarkers of aging. F1000Res. 2017 Jun 9;6:860. doi: 10.12688/f1000research.10692.1. eCollection 2017. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in TeloTAGGG Telomerase PCR activity in serum | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in DNA methylation | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in blood concentration of advanced glycation end product | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in lipid peroxidation | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in serum FGF21 | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in serum TET2 | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment) | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in facial wrinkling (0-100 scale; higher scores mean worse outcome) | Baseline vs. 6 months | Baseline vs. 6 months post-intervention | |
Secondary | Change in maximal oxygen uptake estimated by step-in-place test | Baseline vs. 6 months | Baseline vs. 6 months post-intervention |
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